ZNF24: Zinc Finger Protein 24 – Gene Overview and Biomedical Significance
Comprehensive gene card, expression, mutations, and disease associations for ZNF24 (KOX17, ZNF191)
Gene Information Card
| Symbol | ZNF24 |
|---|---|
| Full Name | zinc finger protein 24 |
| Gene Type | protein coding |
| Chromosomal Location | 18q12.2 |
| NCBI Gene ID | 7572 ncbi.nlm.nih.gov/gene/7572 |
| Ensembl ID | ENSG00000101558 |
| UniProt ID | P17028 |
| OMIM ID | 194453 |
| HGNC ID | 13043 |
| Aliases | KOX17, ZNF191, ZSCAN3 |
Description
ZNF24 (zinc finger protein 24) encodes a C2H2-type zinc finger transcription factor that contains a SCAN domain. It is involved in transcriptional regulation, cell proliferation, and differentiation. ZNF24 is expressed in multiple tissues and has been implicated in neurodevelopment and cancer. The protein localizes to the nucleus and binds to specific DNA sequences to modulate gene expression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | ZNF24 overexpression may promote tumor growth via transcriptional activation of oncogenes | PMID: 25636800 |
| Colorectal cancer | ZNF24 upregulation correlates with poor prognosis and increased cell proliferation | PMID: 27557513 |
| Neurodevelopmental disorders | ZNF24 variants identified in patients with intellectual disability and autism spectrum disorder | ClinVar: VCV000429496 |
| Glioma | ZNF24 expression is elevated in glioblastoma and associated with aggressive tumor behavior | PMID: 29348620 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Breast | 15.2 | Medium |
| Colon | 10.1 | Medium |
| Liver | 6.7 | Low |
| Kidney | 9.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 18.5 | Embryonic kidney, high expression |
| MCF7 | 22.3 | Breast cancer cell line, elevated |
| HCT116 | 20.1 | Colorectal carcinoma, high |
| U87MG | 25.0 | Glioblastoma, very high |
| HepG2 | 12.0 | Hepatocellular carcinoma, moderate |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | p.Met1? – start loss, likely loss of function |
| c.100C>T | missense | <0.01% | p.Arg34Trp – uncertain significance |
| c.200_201del | frameshift | <0.01% | p.Glu67fs – loss of function |
| c.350G>A | missense | <0.01% | p.Arg117His – likely benign |
Mutation functional classification
Loss of Function (LOF)
Frameshift and start-loss variants are predicted to cause loss of ZNF24 protein function.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in curated databases.
Dominant Negative (DN)
No evidence for dominant-negative effects in current literature.
View complete mutation data：
Gene Ontology (GO)
| • DNA binding (GO:0003677) | • DNA-binding transcription factor activity (GO:0003700) |
| • nucleus (GO:0005634) | • regulation of transcription (GO:0006355) |
| • metal ion binding (GO:0046872) |
Pathways
• Transcriptional regulation by ZNF24
• SCAN domain-containing transcription factors
Protein Summary
ZNF24 is a 368-amino-acid nuclear protein with a SCAN domain and four C2H2 zinc fingers. It functions as a transcriptional regulator, binding to GC-rich DNA sequences. The protein is expressed in many tissues and is implicated in cell growth control. Structural studies show that the zinc fingers mediate sequence-specific DNA binding, while the SCAN domain mediates protein-protein interactions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF24 Knockout HEK293 Cell Line | EDJ-KQ6038 | Human | 7572 | Details Get a Quote |
| ZNF248 Knockout HEK293 Cell Line | EDJ-KQ7755 | Human | 57209 | Details Get a Quote |
| ZNF248 Knockout A-549 Cell Line | EDJ-KQ33200 | Human | 57209 | Details Get a Quote |
| ZNF248 Knockout HCT 116 Cell Line | EDJ-KQ33201 | Human | 57209 | Details Get a Quote |
| ZNF248 Knockout HeLa Cell Line | EDJ-KQ33202 | Human | 57209 | Details Get a Quote |
| ZNF24 Knockout A-549 Cell Line | EDJ-KQ29682 | Human | 7572 | Details Get a Quote |
| ZNF24 Knockout HCT 116 Cell Line | EDJ-KQ29683 | Human | 7572 | Details Get a Quote |
| ZNF24 Knockout HeLa Cell Line | EDJ-KQ29684 | Human | 7572 | Details Get a Quote |
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