ZNF236
Zinc Finger Protein 236: A Krüppel-associated box domain-containing transcription factor implicated in diabetic nephropathy and cancer
Gene Information Card
| Symbol | ZNF236 |
|---|---|
| Full Name | zinc finger protein 236 |
| Gene Type | protein-coding |
| Chromosomal Location | 18q23 |
| NCBI Gene ID | 7776 ncbi.nlm.nih.gov/gene/7776 |
| Ensembl ID | ENSG00000130816 |
| UniProt ID | Q9UL36 |
| OMIM ID | 604760 |
| HGNC ID | 13047 |
| Aliases | KIAA0167, ZNF236A, ZNF236B |
Description
ZNF236 encodes a zinc finger protein containing a Krüppel-associated box (KRAB) domain, characteristic of transcriptional repressors. The protein is involved in regulating gene expression and has been associated with diabetic nephropathy and various cancers. Alternative splicing generates multiple transcript variants.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Diabetic Nephropathy | ZNF236 expression is altered in renal tissues under hyperglycemic conditions, potentially affecting extracellular matrix remodeling. | PMID: 14570709 |
| Pancreatic Cancer | ZNF236 is overexpressed in pancreatic ductal adenocarcinoma and may promote tumor growth. | PMID: 25691885 |
| Colorectal Cancer | ZNF236 expression is upregulated in colorectal cancer tissues and correlates with poor prognosis. | PMID: 29351285 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Kidney | 12.5 | Medium |
| Pancreas | 8.3 | Low |
| Colon | 15.2 | Medium |
| Liver | 6.1 | Low |
| Brain | 3.4 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 18.7 | Embryonic kidney cell line |
| PANC-1 | 22.4 | Pancreatic cancer cell line |
| HCT116 | 20.1 | Colorectal cancer cell line |
| HepG2 | 9.8 | Hepatocellular carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | Missense | 0.01% | p.Arg412Cys; predicted damaging by SIFT |
| c.567_568insA | Frameshift | <0.01% | Loss of function; truncation |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations leading to premature stop codons are predicted to cause loss of function.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Not annotated in major pathway databases
Protein Summary
ZNF236 is a 729-amino acid protein containing a KRAB domain at the N-terminus and multiple C2H2-type zinc finger motifs. It localizes to the nucleus and functions as a transcriptional repressor. The protein is expressed in kidney, pancreas, and colon, with altered levels in diabetic nephropathy and several cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF236 Knockout HEK293 Cell Line | EDJ-KQ6116 | Human | 7776 | Details Get a Quote |
| ZNF236 Knockout HCT 116 Cell Line | EDJ-KQ28572 | Human | 7776 | Details Get a Quote |
| ZNF236 Knockout A-549 Cell Line | EDJ-KQ29871 | Human | 7776 | Details Get a Quote |
| ZNF236 Knockout HeLa Cell Line | EDJ-KQ29872 | Human | 7776 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
