ZNF235: Zinc Finger Protein 235
A Krüppel-associated box (KRAB) zinc finger transcription factor with potential roles in transcriptional regulation and cancer.
Gene Information Card
| Symbol | ZNF235 |
|---|---|
| Full Name | zinc finger protein 235 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.43 |
| NCBI Gene ID | 9310 ncbi.nlm.nih.gov/gene/9310 |
| Ensembl ID | ENSG00000167658 |
| UniProt ID | Q14590 |
| OMIM ID | 604752 |
| HGNC ID | 13037 |
| Aliases | ZNF235, ZNF91L, ZNF235L, FLJ23577 |
Description
ZNF235 (zinc finger protein 235) is a protein-coding gene located on chromosome 19q13.43. It encodes a member of the Krüppel-associated box (KRAB) zinc finger protein family, which functions as a transcriptional repressor. The protein contains multiple C2H2-type zinc finger domains and a KRAB domain, suggesting a role in regulating gene expression through chromatin remodeling. ZNF235 is expressed in various tissues and has been implicated in cellular differentiation and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered expression may contribute to tumorigenesis through transcriptional dysregulation. | NCBI Gene, COSMIC |
| Lung cancer | Mutations and copy number alterations observed in lung adenocarcinoma. | COSMIC, ClinVar |
| Colorectal cancer | Differential expression reported in colorectal tumor samples. | NCBI Gene, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.3 | Low |
| Lung | 6.1 | Low |
| Liver | 4.2 | Low |
| Kidney | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | Embryonic kidney cells; moderate expression |
| HeLa | 9.7 | Cervical cancer cells; low expression |
| A549 | 7.4 | Lung cancer cells; low expression |
| MCF7 | 5.1 | Breast cancer cells; very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | Missense | <0.01% | p.Pro412Ser; uncertain significance |
| c.567_568insA | Frameshift | <0.01% | Predicted loss of function |
| c.890G>A | Nonsense | <0.01% | p.Trp297*; predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations are predicted to cause loss of function by truncating the protein.
Gain of Function (GOF)
No gain-of-function mutations have been reported.
Dominant Negative (DN)
No dominant-negative mutations have been characterized.
View complete mutation data：
Gene Ontology (GO)
Pathways
• No specific pathways have been curated for ZNF235 in major databases.
Protein Summary
ZNF235 encodes a 673-amino acid protein with an N-terminal KRAB domain and 12 C2H2-type zinc finger motifs. The KRAB domain mediates transcriptional repression through recruitment of chromatin-modifying complexes, while the zinc fingers facilitate sequence-specific DNA binding. The protein is predominantly nuclear and is thought to regulate genes involved in cell proliferation and differentiation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF235 Knockout HEK293 Cell Line | EDJ-KQ6540 | Human | 9310 | Details Get a Quote |
| ZNF235 Knockout A-549 Cell Line | EDJ-KQ30714 | Human | 9310 | Details Get a Quote |
| ZNF235 Knockout HCT 116 Cell Line | EDJ-KQ30715 | Human | 9310 | Details Get a Quote |
| ZNF235 Knockout HeLa Cell Line | EDJ-KQ30716 | Human | 9310 | Details Get a Quote |
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