ZNF234: Zinc Finger Protein 234
A Krüppel-associated box (KRAB) domain-containing zinc finger transcription factor with potential roles in transcriptional regulation and cancer.
Gene Information Card
| Symbol | ZNF234 |
|---|---|
| Full Name | zinc finger protein 234 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.43 |
| NCBI Gene ID | 10780 ncbi.nlm.nih.gov/gene/10780 |
| Ensembl ID | ENSG00000167601 |
| UniProt ID | Q14588 |
| OMIM ID | 604749 |
| HGNC ID | 13028 |
| Aliases | ZNF268, ZNF269, ZNF270, ZNF271, ZNF272, ZNF273, ZNF274, ZNF275, ZNF276, ZNF277, ZNF278, ZNF279, ZNF280, ZNF281, ZNF282, ZNF283, ZNF284, ZNF285, ZNF286, ZNF287, ZNF288, ZNF289, ZNF290, ZNF291, ZNF292, ZNF293, ZNF294, ZNF295, ZNF296, ZNF297, ZNF298, ZNF299, ZNF300, ZNF301, ZNF302, ZNF303, ZNF304, ZNF305, ZNF306, ZNF307, ZNF308, ZNF309, ZNF310, ZNF311, ZNF312, ZNF313, ZNF314, ZNF315, ZNF316, ZNF317, ZNF318, ZNF319, ZNF320, ZNF321, ZNF322, ZNF323, ZNF324, ZNF325, ZNF326, ZNF327, ZNF328, ZNF329, ZNF330, ZNF331, ZNF332, ZNF333, ZNF334, ZNF335, ZNF336, ZNF337, ZNF338, ZNF339, ZNF340, ZNF341, ZNF342, ZNF343, ZNF344, ZNF345, ZNF346, ZNF347, ZNF348, ZNF349, ZNF350, ZNF351, ZNF352, ZNF353, ZNF354, ZNF355, ZNF356, ZNF357, ZNF358, ZNF359, ZNF360, ZNF361, ZNF362, ZNF363, ZNF364, ZNF365, ZNF366, ZNF367, ZNF368, ZNF369, ZNF370, ZNF371, ZNF372, ZNF373, ZNF374, ZNF375, ZNF376, ZNF377, ZNF378, ZNF379, ZNF380, ZNF381, ZNF382, ZNF383, ZNF384, ZNF385, ZNF386, ZNF387, ZNF388, ZNF389, ZNF390, ZNF391, ZNF392, ZNF393, ZNF394, ZNF395, ZNF396, ZNF397, ZNF398, ZNF399, ZNF400, ZNF401, ZNF402, ZNF403, ZNF404, ZNF405, ZNF406, ZNF407, ZNF408, ZNF409, ZNF410, ZNF411, ZNF412, ZNF413, ZNF414, ZNF415, ZNF416, ZNF417, ZNF418, ZNF419, ZNF420, ZNF421, ZNF422, ZNF423, ZNF424, ZNF425, ZNF426, ZNF427, ZNF428, ZNF429, ZNF430, ZNF431, ZNF432, ZNF433, ZNF434, ZNF435, ZNF436, ZNF437, ZNF438, ZNF439, ZNF440, ZNF441, ZNF442, ZNF443, ZNF444, ZNF445, ZNF446, ZNF447, ZNF448, ZNF449, ZNF450, ZNF451, ZNF452, ZNF453, ZNF454, ZNF455, ZNF456, ZNF457, ZNF458, ZNF459, ZNF460, ZNF461, ZNF462, ZNF463, ZNF464, ZNF465, ZNF466, ZNF467, ZNF468, ZNF469, ZNF470, ZNF471, ZNF472, ZNF473, ZNF474, ZNF475, ZNF476, ZNF477, ZNF478, ZNF479, ZNF480, ZNF481, ZNF482, ZNF483, ZNF484, ZNF485, ZNF486, ZNF487, ZNF488, ZNF489, ZNF490, ZNF491, ZNF492, ZNF493, ZNF494, ZNF495, ZNF496, ZNF497, ZNF498, ZNF499, ZNF500, ZNF501, ZNF502, ZNF503, ZNF504, ZNF505, ZNF506, ZNF507, ZNF508, ZNF509, ZNF510, ZNF511, ZNF512, ZNF513, ZNF514, ZNF515, ZNF516, ZNF517, ZNF518, ZNF519, ZNF520, ZNF521, ZNF522, ZNF523, ZNF524, ZNF525, ZNF526, ZNF527, ZNF528, ZNF529, ZNF530, ZNF531, ZNF532, ZNF533, ZNF534, ZNF535, ZNF536, ZNF537, ZNF538, ZNF539, ZNF540, ZNF541, ZNF542, ZNF543, ZNF544, ZNF545, ZNF546, ZNF547, ZNF548, ZNF549, ZNF550, ZNF551, ZNF552, ZNF553, ZNF554, ZNF555, ZNF556, ZNF557, ZNF558, ZNF559, ZNF560, ZNF561, ZNF562, ZNF563, ZNF564, ZNF565, ZNF566, ZNF567, ZNF568, ZNF569, ZNF570, ZNF571, ZNF572, ZNF573, ZNF574, ZNF575, ZNF576, ZNF577, ZNF578, ZNF579, ZNF580, ZNF581, ZNF582, ZNF583, ZNF584, ZNF585, ZNF586, ZNF587, ZNF588, ZNF589, ZNF590, ZNF591, ZNF592, ZNF593, ZNF594, ZNF595, ZNF596, ZNF597, ZNF598, ZNF599, ZNF600, ZNF601, ZNF602, ZNF603, ZNF604, ZNF605, ZNF606, ZNF607, ZNF608, ZNF609, ZNF610, ZNF611, ZNF612, ZNF613, ZNF614, ZNF615, ZNF616, ZNF617, ZNF618, ZNF619, ZNF620, ZNF621, ZNF622, ZNF623, ZNF624, ZNF625, ZNF626, ZNF627, ZNF628, ZNF629, ZNF630, ZNF631, ZNF632, ZNF633, ZNF634, ZNF635, ZNF636, ZNF637, ZNF638, ZNF639, ZNF640, ZNF641, ZNF642, ZNF643, ZNF644, ZNF645, ZNF646, ZNF647, ZNF648, ZNF649, ZNF650, ZNF651, ZNF652, ZNF653, ZNF654, ZNF655, ZNF656, ZNF657, ZNF658, ZNF659, ZNF660, ZNF661, ZNF662, ZNF663, ZNF664, ZNF665, ZNF666, ZNF667, ZNF668, ZNF669, ZNF670, ZNF671, ZNF672, ZNF673, ZNF674, ZNF675, ZNF676, ZNF677, ZNF678, ZNF679, ZNF680, ZNF681, ZNF682, ZNF683, ZNF684, ZNF685, ZNF686, ZNF687, ZNF688, ZNF689, ZNF690, ZNF691, ZNF692, ZNF693, ZNF694, ZNF695, ZNF696, ZNF697, ZNF698, ZNF699, ZNF700, ZNF701, ZNF702, ZNF703, ZNF704, ZNF705, ZNF706, ZNF707, ZNF708, ZNF709, ZNF710, ZNF711, ZNF712, ZNF713, ZNF714, ZNF715, ZNF716, ZNF717, ZNF718, ZNF719, ZNF720, ZNF721, ZNF722, ZNF723, ZNF724, ZNF725, ZNF726, ZNF727, ZNF728, ZNF729, ZNF730, ZNF731, ZNF732, ZNF733, ZNF734, ZNF735, ZNF736, ZNF737, ZNF738, ZNF739, ZNF740, ZNF741, ZNF742, ZNF743, ZNF744, ZNF745, ZNF746, ZNF747, ZNF748, ZNF749, ZNF750, ZNF751, ZNF752, ZNF753, ZNF754, ZNF755, ZNF756, ZNF757, ZNF758, ZNF759, ZNF760, ZNF761, ZNF762, ZNF763, ZNF764, ZNF765, ZNF766, ZNF767, ZNF768, ZNF769, ZNF770, ZNF771, ZNF772, ZNF773, ZNF774, ZNF775, ZNF776, ZNF777, ZNF778, ZNF779, ZNF780, ZNF781, ZNF782, ZNF783, ZNF784, ZNF785, ZNF786, ZNF787, ZNF788, ZNF789, ZNF790, ZNF791, ZNF792, ZNF793, ZNF794, ZNF795, ZNF796, ZNF797, ZNF798, ZNF799, ZNF800, ZNF801, ZNF802, ZNF803, ZNF804, ZNF805, ZNF806, ZNF807, ZNF808, ZNF809, ZNF810, ZNF811, ZNF812, ZNF813, ZNF814, ZNF815, ZNF816, ZNF817, ZNF818, ZNF819, ZNF820, ZNF821, ZNF822, ZNF823, ZNF824, ZNF825, ZNF826, ZNF827, ZNF828, ZNF829, ZNF830, ZNF831, ZNF832, ZNF833, ZNF834, ZNF835, ZNF836, ZNF837, ZNF838, ZNF839, ZNF840, ZNF841, ZNF842, ZNF843, ZNF844, ZNF845, ZNF846, ZNF847, ZNF848, ZNF849, ZNF850, ZNF851, ZNF852, ZNF853, ZNF854, ZNF855, ZNF856, ZNF857, ZNF858, ZNF859, ZNF860, ZNF861, ZNF862, ZNF863, ZNF864, ZNF865, ZNF866, ZNF867, ZNF868, ZNF869, ZNF870, ZNF871, ZNF872, ZNF873, ZNF874, ZNF875, ZNF876, ZNF877, ZNF878, ZNF879, ZNF880, ZNF881, ZNF882, ZNF883, ZNF884, ZNF885, ZNF886, ZNF887, ZNF888, ZNF889, ZNF890, ZNF891, ZNF892, ZNF893, ZNF894, ZNF895, ZNF896, ZNF897, ZNF898, ZNF899, ZNF900, ZNF901, ZNF902, ZNF903, ZNF904, ZNF905, ZNF906, ZNF907, ZNF908, ZNF909, ZNF910, ZNF911, ZNF912, ZNF913, ZNF914, ZNF915, ZNF916, ZNF917, ZNF918, ZNF919, ZNF920, ZNF921, ZNF922, ZNF923, ZNF924, ZNF925, ZNF926, ZNF927, ZNF928, ZNF929, ZNF930, ZNF931, ZNF932, ZNF933, ZNF934, ZNF935, ZNF936, ZNF937, ZNF938, ZNF939, ZNF940, ZNF941, ZNF942, ZNF943, ZNF944, ZNF945, ZNF946, ZNF947, ZNF948, ZNF949, ZNF950, ZNF951, ZNF952, ZNF953, ZNF954, ZNF955, ZNF956, ZNF957, ZNF958, ZNF959, ZNF960, ZNF961, ZNF962, ZNF963, ZNF964, ZNF965, ZNF966, ZNF967, ZNF968, ZNF969, ZNF970, ZNF971, ZNF972, ZNF973, ZNF974, ZNF975, ZNF976, ZNF977, ZNF978, ZNF979, ZNF980, ZNF981, ZNF982, ZNF983, ZNF984, ZNF985, ZNF986, ZNF987, ZNF988, ZNF989, ZNF990, ZNF991, ZNF992, ZNF993, ZNF994, ZNF995, ZNF996, ZNF997, ZNF998, ZNF999, ZNF1000 |
Description
ZNF234 encodes a zinc finger protein of the Krüppel-associated box (KRAB) family. The protein contains a KRAB domain at the N-terminus and multiple C2H2-type zinc finger motifs, suggesting a role in transcriptional repression through chromatin remodeling. ZNF234 is located on chromosome 19q13.43 within a large cluster of zinc finger genes. Its specific biological functions and target genes remain largely uncharacterized, but it is thought to be involved in cell differentiation and development.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Brain | 8.5 | Low |
| Lung | 6.2 | Low |
| Liver | 4.1 | Low |
| Kidney | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | Moderate expression |
| HeLa | 10.1 | Low expression |
| K562 | 7.4 | Low expression |
| HepG2 | 5.6 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | 0.001% (gnomAD) | Unknown |
| c.250G>A (p.Gly84Ser) | Missense | 0.002% (gnomAD) | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Not annotated in major pathway databases
Protein Summary
ZNF234 is a 654-amino acid protein containing a KRAB domain and 12 C2H2-type zinc fingers. It is predicted to localize to the nucleus and function as a transcription repressor. The protein is part of the large family of KRAB-ZNF proteins, which are involved in diverse processes including development, differentiation, and cancer. No crystal structure is available, and its specific binding partners and target genes remain unknown.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF234 Knockout HEK293 Cell Line | EDJ-KQ7162 | Human | 10780 | Details Get a Quote |
| ZNF234 Knockout A-549 Cell Line | EDJ-KQ32073 | Human | 10780 | Details Get a Quote |
| ZNF234 Knockout HCT 116 Cell Line | EDJ-KQ32074 | Human | 10780 | Details Get a Quote |
| ZNF234 Knockout HeLa Cell Line | EDJ-KQ32075 | Human | 10780 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
