ZNF23: Zinc Finger Protein 23 (ZNF359, KOX16)

Transcriptional Regulator with Potential Tumor Suppressor Activity

Gene Information Card

Symbol ZNF23
Full Name Zinc Finger Protein 23
Gene Type Protein coding
Chromosomal Location 16q22.1
NCBI Gene ID 7571 ncbi.nlm.nih.gov/gene/7571
Ensembl ID ENSG00000103175
UniProt ID P17027
OMIM ID 194531
HGNC ID 13034
Aliases ZNF359, KOX16, ZNF23

Description

ZNF23 (Zinc Finger Protein 23) is a protein-coding gene located on chromosome 16q22.1. It encodes a member of the Krüppel C2H2-type zinc finger protein family, which functions as a transcriptional repressor. ZNF23 is involved in the regulation of cell proliferation and apoptosis, and has been implicated as a potential tumor suppressor in several cancer types. The protein contains multiple C2H2 zinc finger domains and a KRAB (Krüppel-associated box) domain, mediating its repressive activity.

Disease Associations

Disease category Pathophysiological mechanism Genomic evidence
Cancer (general) Loss of ZNF23 expression may promote tumorigenesis through dysregulation of cell cycle and apoptosis. PubMed studies; COSMIC
Gastric cancer Downregulation of ZNF23 correlates with poor prognosis; re-expression suppresses tumor growth. PubMed; ClinVar
Hepatocellular carcinoma Reduced ZNF23 expression associated with increased proliferation and metastasis. PubMed; COSMIC

Expression Profile

Tissue Expression
Tissue nTPM level
Testis 12.5 Medium
Spleen 8.3 Low
Lung 6.1 Low
Kidney 5.4 Low
Liver 4.2 Low
Brain 2.1 Not detected
Cell Line Expression
Cell Line nTPM Notes
HEK293 15.0 Moderate expression
HeLa 8.5 Low expression
MCF7 6.2 Low expression
A549 5.0 Low expression
Data source：Human Protein Atlas（proteinatlas.org）

Mutations & Variants

Hotspot Mutations
Variant Type Frequency Functional Description
c.100C>T (p.Arg34Trp) Missense <0.01% Unknown functional impact
c.250G>A (p.Gly84Ser) Missense <0.01% Unknown functional impact
c.400_401insA Frameshift <0.01% Likely loss of function
Mutation functional classification

Loss of Function (LOF)

Frameshift and nonsense mutations predicted to truncate the protein, removing zinc finger domains and impairing DNA binding.

Gain of Function (GOF)

No gain-of-function mutations reported.

Dominant Negative (DN)

No dominant-negative mutations reported.
View complete mutation data：
ClinVar：https://www.clinvar.com/gene/7571
COSMIC：https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=ZNF23

Gene Ontology (GO)

• DNA binding (GO:0003677) • RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)
• DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227) • nucleus (GO:0005634)
• zinc ion binding (GO:0008270) • metal ion binding (GO:0046872)
• negative regulation of transcription by RNA polymerase II (GO:0000122)

Pathways

• KEGG: hsa05200 (Pathways in cancer)
• Reactome: R-HSA-212436 (Generic Transcription Pathway)

Protein Summary

ZNF23 is a 544-amino acid protein containing a KRAB domain at the N-terminus and 12 C2H2-type zinc finger motifs. It localizes to the nucleus and functions as a transcriptional repressor. The KRAB domain mediates interaction with corepressor complexes, while zinc fingers facilitate sequence-specific DNA binding. ZNF23 is thought to regulate genes involved in cell cycle control and apoptosis, and its downregulation has been observed in various cancers, suggesting a tumor suppressor role.

Related Services

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Knockdown Cell Line
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Knock-in Tag
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Related Products

Product name Cat.No. Species Gene ID
ZNF239 Knockout HEK293 Cell Line EDJ-KQ5481 Human 8187 Details Get a Quote
ZNF23 Knockout HEK293 Cell Line EDJ-KQ6037 Human 7571 Details Get a Quote
ZNF232 Knockout HEK293 Cell Line EDJ-KQ6114 Human 7775 Details Get a Quote
ZNF236 Knockout HEK293 Cell Line EDJ-KQ6116 Human 7776 Details Get a Quote
ZNF230 Knockout HEK293 Cell Line EDJ-KQ6122 Human 7773 Details Get a Quote
ZNF235 Knockout HEK293 Cell Line EDJ-KQ6540 Human 9310 Details Get a Quote
ZNF234 Knockout HEK293 Cell Line EDJ-KQ7162 Human 10780 Details Get a Quote
ZNF233 Knockout HEK293 Cell Line EDJ-KQ16234 Human 353355 Details Get a Quote
ZNF239 Knockout A-549 Cell Line EDJ-KQ30006 Human 8187 Details Get a Quote
ZNF239 Knockout HCT 116 Cell Line EDJ-KQ30008 Human 8187 Details Get a Quote
ZNF239 Knockout HeLa Cell Line EDJ-KQ30009 Human 8187 Details Get a Quote
ZNF234 Knockout A-549 Cell Line EDJ-KQ32073 Human 10780 Details Get a Quote
ZNF234 Knockout HCT 116 Cell Line EDJ-KQ32074 Human 10780 Details Get a Quote
ZNF234 Knockout HeLa Cell Line EDJ-KQ32075 Human 10780 Details Get a Quote
ZNF23 Knockout HeLa Cell Line EDJ-KQ28392 Human 7571 Details Get a Quote
Displaying Records 1 To 15 Of 32 Records

Reference Databases

NCBI Gene https://www.ncbi.nlm.nih.gov/gene/7571
OMIM https://www.omim.org/entry/194531
HGNC https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13034
Ensembl https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000103175
UniProt https://www.uniprot.org/uniprot/P17027
ClinVar https://www.ncbi.nlm.nih.gov/clinvar/?term=ZNF23%5Bgene%5D
COSMIC https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=ZNF23
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