ZNF223: Zinc Finger Protein 223
A KRAB-Zinc Finger Transcription Factor with Emerging Roles in Gene Regulation
Gene Information Card
| Symbol | ZNF223 |
|---|---|
| Full Name | zinc finger protein 223 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.43 |
| NCBI Gene ID | 7766 ncbi.nlm.nih.gov/gene/7766 |
| Ensembl ID | ENSG00000167601 |
| UniProt ID | Q9UK11 |
| OMIM ID | 604078 |
| HGNC ID | 13066 |
| Aliases | ZNF223, ZNF223_HUMAN |
Description
ZNF223 encodes a zinc finger protein of the Krüppel-associated box (KRAB) family. The protein contains multiple C2H2-type zinc finger domains and a KRAB domain, suggesting a role in transcriptional repression. ZNF223 is part of a cluster of zinc finger genes on chromosome 19q13.43 and is widely expressed in various tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association established | Not determined | No direct evidence from ClinVar, OMIM, or COSMIC as of current data |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 8.2 | Low |
| Spleen | 7.1 | Low |
| Bone marrow | 6.8 | Low |
| Brain | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 9.5 | Embryonic kidney cells |
| K562 | 7.8 | Leukemia cell line |
| HeLa | 6.2 | Cervical cancer cells |
| HepG2 | 5.1 | Liver cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | N/A | N/A | No COSMIC or ClinVar entries for ZNF223 |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • nucleic acid binding (GO:0003676) | • DNA binding (GO:0003677) |
| • zinc ion binding (GO:0008270) | • nucleus (GO:0005634) |
| • metal ion binding (GO:0046872) |
Protein Summary
ZNF223 is a 548-amino acid protein containing a KRAB domain at the N-terminus and 12 C2H2-type zinc finger motifs. It is predicted to localize to the nucleus and function as a transcription repressor via the KRAB domain. The protein is part of the large family of KRAB-ZNF proteins involved in regulating gene expression, particularly in immune and reproductive tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF223 Knockout HEK293 Cell Line | EDJ-KQ6107 | Human | 7766 | Details Get a Quote |
| ZNF223 Knockout A-549 Cell Line | EDJ-KQ29847 | Human | 7766 | Details Get a Quote |
| ZNF223 Knockout HeLa Cell Line | EDJ-KQ29848 | Human | 7766 | Details Get a Quote |
| ZNF223 Knockout HCT 116 Cell Line | EDJ-KQ71749 | Human | 7766 | Details Get a Quote |
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