ZNF214 Gene: Function, Expression, and Disease Associations | Biomedical Database

ZNF214 (zinc finger protein 214) is a protein-coding gene located on chromosome 19p13.2. It encodes a zinc finger protein containing a KRAB (Krüppel-associated box) domain and multiple C2H2-type zinc finger motifs, suggesting a role in transcriptional regulation. The protein is predicted to function as a transcription factor, potentially involved in DNA binding and regulation of gene expression. ZNF214 is part of the large family of KRAB zinc finger proteins, which are involved in diverse processes including development, differentiation, and response to cellular stress. Expression data indicate broad but variable expression across tissues, with highest levels in the testis and certain brain regions. While specific disease associations are not yet well-established, its structural features and expression patterns suggest potential roles in cancer and neurological disorders, warranting further investigation.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• No specific pathways are curated for ZNF214 in major databases.

The ZNF214 protein is a KRAB zinc finger transcription factor. It contains a KRAB domain at the N-terminus, which is often involved in recruiting co-repressor complexes, and multiple C2H2 zinc finger motifs that mediate sequence-specific DNA binding. The protein is predicted to localize to the nucleus and regulate gene expression. Its exact target genes and biological functions remain largely uncharacterized, but its expression in testis and brain suggests roles in spermatogenesis and neuronal function. Structural predictions indicate a typical architecture for KRAB-ZNF proteins, with the zinc finger array likely recognizing specific DNA motifs.