ZNF213: Zinc Finger Protein 213
A KRAB-Zinc Finger Protein with Potential Roles in Transcriptional Regulation and Disease
Gene Information Card
| Symbol | ZNF213 |
|---|---|
| Full Name | zinc finger protein 213 |
| Gene Type | protein-coding |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | 7760 ncbi.nlm.nih.gov/gene/7760 |
| Ensembl ID | ENSG00000196419 |
| UniProt ID | Q9Y2G9 |
| OMIM ID | 605013 |
| HGNC ID | 13049 |
| Aliases | ZNF213, ZKSCAN21, ZNF213-AS1 |
Description
ZNF213 (zinc finger protein 213) is a protein-coding gene located on chromosome 16p13.3. It belongs to the Krüppel-associated box (KRAB) zinc finger protein family, which are transcriptional repressors involved in diverse biological processes including development, differentiation, and apoptosis. The encoded protein contains a KRAB domain and multiple C2H2-type zinc finger motifs, suggesting a role in DNA binding and transcriptional regulation. ZNF213 has been implicated in cancer and other diseases through its potential involvement in gene silencing and chromatin remodeling.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Potential dysregulation of ZNF213 expression may contribute to tumorigenesis via altered transcriptional repression of target genes. | Limited evidence from expression studies and COSMIC mutation data. |
| Colorectal cancer | Somatic mutations and copy number alterations in ZNF213 have been reported in colorectal tumors, suggesting a possible role in cancer progression. | COSMIC database; limited functional validation. |
| Hepatocellular carcinoma | ZNF213 expression changes observed in liver cancer tissues, possibly affecting cell proliferation pathways. | Expression profiling studies; not yet confirmed by large-scale cohorts. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Bone marrow | 8.7 | Low |
| Lymph node | 6.5 | Low |
| Brain | 4.2 | Low |
| Liver | 3.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | Moderate expression in embryonic kidney cells |
| HeLa | 10.8 | Detectable expression in cervical cancer cells |
| K562 | 9.4 | Low expression in leukemia cells |
| MCF7 | 7.1 | Low expression in breast cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Pro34Leu) | Missense | <0.01% | Unknown; rare variant in population databases |
| c.205G>A (p.Gly69Arg) | Missense | <0.01% | Unknown; predicted possibly damaging |
| c.412_413insA | Frameshift | <0.01% | Likely loss of function; truncation of protein |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.412_413insA) are predicted to cause premature termination, likely resulting in loss of transcriptional repressor activity.
Gain of Function (GOF)
No documented gain-of-function mutations for ZNF213.
Dominant Negative (DN)
No evidence of dominant-negative effects for ZNF213 mutations.
View complete mutation data：
Gene Ontology (GO)
| • DNA-binding transcription factor activity | • zinc ion binding |
| • regulation of transcription by RNA polymerase II | • nucleus |
| • chromatin binding |
Pathways
• No specific curated pathways; predicted involvement in transcriptional regulation via KRAB-ZNF family interactions.
Protein Summary
ZNF213 encodes a KRAB domain-containing zinc finger protein of 569 amino acids. The protein localizes to the nucleus and is predicted to function as a transcriptional repressor by binding to specific DNA sequences via its C2H2 zinc fingers. The KRAB domain mediates interaction with KAP1/TRIM28, recruiting chromatin-modifying complexes to silence gene expression. ZNF213 may play roles in cell differentiation and cancer, though its specific target genes remain largely uncharacterized.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF213 Knockout HEK293 Cell Line | EDJ-KQ6104 | Human | 7760 | Details Get a Quote |
| ZNF213 Knockout HCT 116 Cell Line | EDJ-KQ28543 | Human | 7760 | Details Get a Quote |
| ZNF213 Knockout A-549 Cell Line | EDJ-KQ29843 | Human | 7760 | Details Get a Quote |
| ZNF213 Knockout HeLa Cell Line | EDJ-KQ29844 | Human | 7760 | Details Get a Quote |
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