ZNF205: Zinc Finger Protein 205
Transcriptional Regulator with Potential Roles in Development and Disease
Gene Information Card
| Symbol | ZNF205 |
|---|---|
| Full Name | zinc finger protein 205 |
| Gene Type | protein-coding |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | 7755 ncbi.nlm.nih.gov/gene/7755 |
| Ensembl ID | ENSG00000103197 |
| UniProt ID | O95201 |
| OMIM ID | 603902 |
| HGNC ID | 13002 |
| Aliases | ZNF210, ZNF205-AS1 |
Description
ZNF205 (zinc finger protein 205) is a protein-coding gene located on chromosome 16p13.3. It encodes a member of the Krüppel-associated box (KRAB) zinc finger protein family, which functions as a transcriptional repressor. The protein contains multiple C2H2-type zinc finger domains and a KRAB domain, suggesting a role in regulating gene expression through chromatin remodeling and transcriptional silencing. ZNF205 is expressed in various tissues and may be involved in developmental processes and cellular differentiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not established | No curated evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Brain | 8.7 | Low |
| Lung | 6.5 | Low |
| Liver | 4.2 | Low |
| Kidney | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | Moderate expression |
| HeLa | 10.8 | Moderate expression |
| K562 | 7.3 | Low expression |
| MCF7 | 6.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | missense | <0.01% | Unknown significance |
| c.567delA | frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.567delA) likely result in truncated protein and loss of transcriptional repressor activity.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • DNA-binding transcription factor activity | • zinc ion binding |
| • nucleus | • regulation of transcription by RNA polymerase II |
| • negative regulation of transcription |
Pathways
• No specific pathways curated
Protein Summary
ZNF205 is a 654-amino acid protein containing a KRAB domain at the N-terminus and 12 C2H2-type zinc finger motifs. It localizes to the nucleus and acts as a transcriptional repressor by recruiting chromatin-modifying complexes. The protein is expressed in multiple tissues, with highest levels in testis. Its precise biological functions remain under investigation, but it may play roles in cell differentiation and development.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF205 Knockout HEK293 Cell Line | EDJ-KQ6111 | Human | 7755 | Details Get a Quote |
| ZNF205 Knockout A-549 Cell Line | EDJ-KQ29860 | Human | 7755 | Details Get a Quote |
| ZNF205 Knockout HCT 116 Cell Line | EDJ-KQ29861 | Human | 7755 | Details Get a Quote |
| ZNF205 Knockout HeLa Cell Line | EDJ-KQ29862 | Human | 7755 | Details Get a Quote |
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