ZNF200
Zinc Finger Protein 200: A C2H2-Type Transcription Regulator
Gene Information Card
| Symbol | ZNF200 |
|---|---|
| Full Name | zinc finger protein 200 |
| Gene Type | protein-coding |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | 7752 ncbi.nlm.nih.gov/gene/7752 |
| Ensembl ID | ENSG00000196419 |
| UniProt ID | O60306 |
| OMIM ID | 603975 |
| HGNC ID | 13001 |
| Aliases | ZNF200, ZNF-200, FLJ20489 |
Description
ZNF200 encodes a C2H2-type zinc finger protein, a member of the Krüppel-associated box (KRAB) zinc finger family. The protein is predicted to function as a transcription regulator, binding DNA via its zinc finger domains and potentially repressing transcription through the KRAB domain. It is located on chromosome 16p13.3 and is expressed in multiple tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in curated databases | Not established | No evidence in OMIM, ClinVar, or COSMIC as of current data |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 8.2 | Medium |
| Brain | 5.1 | Low |
| Lung | 4.3 | Low |
| Liver | 3.8 | Low |
| Kidney | 3.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 6.0 | Moderate expression in RNA-seq |
| K562 | 4.5 | Low expression |
| HeLa | 3.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function variants in curated databases.
Gain of Function (GOF)
No documented gain-of-function variants in curated databases.
Dominant Negative (DN)
No documented dominant-negative variants in curated databases.
View complete mutation data：
Gene Ontology (GO)
| • DNA binding (GO:0003677) | • zinc ion binding (GO:0008270) |
| • nucleus (GO:0005634) | • metal ion binding (GO:0046872) |
| • RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978) |
Pathways
• No specific pathway annotations in Reactome or KEGG for ZNF200
Protein Summary
ZNF200 is a 532-amino acid protein containing multiple C2H2-type zinc finger domains and a KRAB domain. It localizes to the nucleus and is predicted to act as a sequence-specific DNA-binding transcription repressor. The protein is encoded by a gene on chromosome 16p13.3 and is expressed at low to moderate levels across various tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF200 Knockout HEK293 Cell Line | EDJ-KQ6098 | Human | 7752 | Details Get a Quote |
| ZNF200 Knockout HCT 116 Cell Line | EDJ-KQ28529 | Human | 7752 | Details Get a Quote |
| ZNF200 Knockout A-549 Cell Line | EDJ-KQ29829 | Human | 7752 | Details Get a Quote |
| ZNF200 Knockout HeLa Cell Line | EDJ-KQ29831 | Human | 7752 | Details Get a Quote |
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