ZNF20: Zinc Finger Protein 20 - Gene Overview
Comprehensive biomedical resource for ZNF20, including genomic data, expression, and disease associations.
Gene Information Card
| Symbol | ZNF20 |
|---|---|
| Full Name | zinc finger protein 20 |
| Gene Type | protein-coding |
| Chromosomal Location | 19p13.2 |
| NCBI Gene ID | 7568 ncbi.nlm.nih.gov/gene/7568 |
| Ensembl ID | ENSG00000167552 |
| UniProt ID | P17024 |
| OMIM ID | 194541 |
| HGNC ID | 13034 |
| Aliases | KOX16, ZNF31, ZNF20 |
Description
ZNF20 (zinc finger protein 20) is a protein-coding gene located on chromosome 19p13.2. It encodes a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family, which functions as a transcription repressor. The protein contains multiple C2H2-type zinc finger domains and is involved in transcriptional regulation, potentially playing roles in development and cellular differentiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not established | No direct evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.1 | Low |
| Liver | 4.3 | Low |
| Kidney | 5.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.1 | Embryonic kidney cells |
| HeLa | 7.8 | Cervical cancer cells |
| K562 | 6.5 | Leukemia cells |
| HepG2 | 5.2 | Liver cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T | missense | 0.01% | p.Arg34Cys; unknown significance |
| c.250G>A | missense | 0.005% | p.Gly84Ser; unknown significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • DNA-binding transcription factor activity (GO:0003700) | • zinc ion binding (GO:0008270) |
| • nucleus (GO:0005634) | • DNA-templated (GO:0006355) |
Pathways
• No specific pathways curated in Reactome or KEGG for ZNF20.
Protein Summary
ZNF20 is a 544-amino acid protein containing a KRAB domain at the N-terminus and 12 C2H2-type zinc finger motifs. It localizes to the nucleus and acts as a transcriptional repressor by recruiting chromatin-modifying complexes. The protein is expressed in multiple tissues, with highest levels in testis. Its precise biological functions remain under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF20 Knockout HEK293 Cell Line | EDJ-KQ6039 | Human | 7568 | Details Get a Quote |
| ZNF200 Knockout HEK293 Cell Line | EDJ-KQ6098 | Human | 7752 | Details Get a Quote |
| ZNF202 Knockout HEK293 Cell Line | EDJ-KQ6102 | Human | 7753 | Details Get a Quote |
| ZNF205 Knockout HEK293 Cell Line | EDJ-KQ6111 | Human | 7755 | Details Get a Quote |
| ZNF200 Knockout HCT 116 Cell Line | EDJ-KQ28529 | Human | 7752 | Details Get a Quote |
| ZNF202 Knockout A-549 Cell Line | EDJ-KQ28536 | Human | 7753 | Details Get a Quote |
| ZNF20 Knockout HeLa Cell Line | EDJ-KQ29685 | Human | 7568 | Details Get a Quote |
| ZNF200 Knockout A-549 Cell Line | EDJ-KQ29829 | Human | 7752 | Details Get a Quote |
| ZNF200 Knockout HeLa Cell Line | EDJ-KQ29831 | Human | 7752 | Details Get a Quote |
| ZNF202 Knockout HCT 116 Cell Line | EDJ-KQ29838 | Human | 7753 | Details Get a Quote |
| ZNF202 Knockout HeLa Cell Line | EDJ-KQ29839 | Human | 7753 | Details Get a Quote |
| ZNF205 Knockout A-549 Cell Line | EDJ-KQ29860 | Human | 7755 | Details Get a Quote |
| ZNF205 Knockout HCT 116 Cell Line | EDJ-KQ29861 | Human | 7755 | Details Get a Quote |
| ZNF205 Knockout HeLa Cell Line | EDJ-KQ29862 | Human | 7755 | Details Get a Quote |
| ZNF208 Knockout HEK293 Cell Line | EDJ-KQ50725 | Human | 7757 | Details Get a Quote |
Displaying Records 1 To 15 Of 20 Records
