ZNF143: A Zinc Finger Transcription Factor with Roles in Gene Regulation and Cancer
Comprehensive gene card for ZNF143, including genomic annotation, expression, mutations, and disease associations.
Gene Information Card
| Symbol | ZNF143 |
|---|---|
| Full Name | zinc finger protein 143 |
| Gene Type | protein-coding |
| Chromosomal Location | 11p15.4 |
| NCBI Gene ID | 7702 ncbi.nlm.nih.gov/gene/7702 |
| Ensembl ID | ENSG00000166479 |
| UniProt ID | P52747 |
| OMIM ID | 603745 |
| HGNC ID | 12927 |
| Aliases | SBF, STAF, Zfp143 |
Description
ZNF143 (zinc finger protein 143) encodes a C2H2-type zinc finger transcription factor that binds to the SphI post-octamer element and activates small nuclear RNA (snRNA) and small nucleolar RNA (snoRNA) gene promoters. It also regulates protein-coding genes involved in cell cycle, DNA repair, and metabolism. ZNF143 is ubiquitously expressed and has been implicated in cancer progression and developmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | ZNF143 overexpression promotes cell proliferation and invasion via transcriptional activation of target genes. | PMID: 29774082 |
| Breast cancer | ZNF143 upregulation correlates with poor prognosis and enhances metastasis through EMT induction. | PMID: 31092905 |
| Hepatocellular carcinoma | ZNF143 silencing reduces tumor growth and induces apoptosis in liver cancer cells. | PMID: 31591469 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | High |
| Thyroid | 12.8 | High |
| Lymph node | 11.5 | High |
| Brain | 8.3 | Medium |
| Liver | 7.1 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.5 | Cervical cancer cell line |
| HepG2 | 12.3 | Liver cancer cell line |
| MCF7 | 10.8 | Breast cancer cell line |
| A549 | 9.6 | Lung cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1045C>T (p.Arg349Trp) | Missense | 0.02% (gnomAD) | Unknown functional effect; located in zinc finger domain |
| c.1234G>A (p.Gly412Arg) | Missense | 0.01% (gnomAD) | May alter DNA-binding affinity |
| c.789_790insA (p.Glu264Argfs*12) | Frameshift | <0.01% (COSMIC) | Loss of function; truncation of C-terminal domain |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations in ZNF143 are predicted to cause loss of DNA-binding and transcriptional activation, potentially impairing snRNA/snoRNA expression.
Gain of Function (GOF)
Missense mutations in the zinc finger region may alter target specificity or increase transcriptional activity, but evidence is limited.
Dominant Negative (DN)
No dominant-negative mutations have been reported for ZNF143.
View complete mutation data：
Gene Ontology (GO)
Pathways
• snRNA transcription by RNA polymerase II
• RNA polymerase III transcription
• Cell cycle regulation
Protein Summary
ZNF143 is a 625-amino acid protein containing seven C2H2-type zinc finger domains. It localizes to the nucleus and functions as a sequence-specific transcription factor. The protein binds to the SphI motif (GTGCC) in snRNA and snoRNA gene promoters and recruits RNA polymerase II/III complexes. ZNF143 also interacts with chromatin remodeling factors and is involved in maintaining genomic stability.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF143 Knockout HEK293 Cell Line | EDJ-KQ50721 | Human | 7702 | Details Get a Quote |
| ZNF143 Knockout HeLa Cell Line | EDJ-KQ54781 | Human | 7702 | Details Get a Quote |
| ZNF143 Knockout A-549 Cell Line | EDJ-KQ63273 | Human | 7702 | Details Get a Quote |
| ZNF143 Knockout HCT 116 Cell Line | EDJ-KQ71739 | Human | 7702 | Details Get a Quote |
