ZNF133: Zinc Finger Protein 133
A KRAB domain-containing zinc finger transcription factor involved in transcriptional repression and potential roles in development and disease.
Gene Information Card
| Symbol | ZNF133 |
|---|---|
| Full Name | zinc finger protein 133 |
| Gene Type | protein-coding |
| Chromosomal Location | 20p11.23 |
| NCBI Gene ID | 7692 ncbi.nlm.nih.gov/gene/7692 |
| Ensembl ID | ENSG00000101986 |
| UniProt ID | P52736 |
| OMIM ID | 604076 |
| HGNC ID | 12962 |
| Aliases | ZNF133L, ZNF133S, pHZ-66, ZKSCAN13 |
Description
ZNF133 encodes a zinc finger protein of the Krüppel-associated box (KRAB) family. The protein contains a KRAB domain at the N-terminus and multiple C2H2-type zinc finger motifs, functioning as a transcriptional repressor through recruitment of chromatin-modifying complexes. It is involved in regulation of gene expression during development and cellular differentiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not established | No curated evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Thyroid | 8.2 | Low |
| Prostate | 7.1 | Low |
| Adrenal gland | 6.8 | Low |
| Lymph node | 5.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.3 | Moderate expression |
| HeLa | 8.7 | Low expression |
| K562 | 6.4 | Low expression |
| HepG2 | 5.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants curated in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function variants in ClinVar or COSMIC.
Gain of Function (GOF)
No documented gain-of-function variants in ClinVar or COSMIC.
Dominant Negative (DN)
No documented dominant-negative variants in ClinVar or COSMIC.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Not annotated in major pathway databases (KEGG
• Reactome
• WikiPathways)
Protein Summary
ZNF133 is a 544-amino acid protein with a KRAB domain (residues 1-75) and 12 C2H2-type zinc finger domains. It localizes to the nucleus and acts as a transcriptional repressor. The KRAB domain mediates interaction with KAP1/TRIM28, recruiting histone deacetylases and methyltransferases to silence target genes. Expression is enriched in testis and several other tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF133 Knockout HEK293 Cell Line | EDJ-KQ16233 | Human | 7692 | Details Get a Quote |
| ZNF133 Knockout A-549 Cell Line | EDJ-KQ47524 | Human | 7692 | Details Get a Quote |
| ZNF133 Knockout HCT 116 Cell Line | EDJ-KQ47525 | Human | 7692 | Details Get a Quote |
| ZNF133 Knockout HeLa Cell Line | EDJ-KQ47526 | Human | 7692 | Details Get a Quote |
| ZNF133 Knockout Hep-G2 Cell Line | EDJ-KZ91 | Human | 7692 | Details Get a Quote |
