ZMYND12
Zinc Finger MYND-Type Containing 12
Gene Information Card
| Symbol | ZMYND12 |
|---|---|
| Full Name | Zinc Finger MYND-Type Containing 12 |
| Gene Type | Protein coding |
| Chromosomal Location | 1p34.3 |
| NCBI Gene ID | 84269 ncbi.nlm.nih.gov/gene/84269 |
| Ensembl ID | ENSG00000162614 |
| UniProt ID | Q9H0C5 |
| OMIM ID | 618511 |
| HGNC ID | 29387 |
| Aliases | FLJ11273, MGC131891 |
Description
ZMYND12 encodes a protein containing a MYND-type zinc finger domain, which is involved in protein-protein interactions and transcriptional regulation. The gene is located on chromosome 1p34.3 and is expressed in various tissues. Its function is not fully characterized, but it may play a role in cellular signaling and development.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Brain | 8.1 | Low |
| Lung | 6.5 | Low |
| Liver | 4.3 | Low |
| Kidney | 5.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 12.0 | Moderate expression |
| HeLa | 9.5 | Low expression |
| K562 | 7.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • nucleic acid binding (GO:0003676) | • zinc ion binding (GO:0008270) |
| • nucleus (GO:0005634) |
Protein Summary
The ZMYND12 protein contains a MYND-type zinc finger domain, which is characteristic of proteins involved in chromatin remodeling and transcriptional regulation. The exact biological function remains unclear, but it is predicted to localize to the nucleus and bind nucleic acids.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZMYND12 Knockout HEK293 Cell Line | EDJ-KQ10016 | Human | 84217 | Details Get a Quote |
| ZMYND12 Knockout HCT 116 Cell Line | EDJ-KQ37005 | Human | 84217 | Details Get a Quote |
| ZMYND12 Knockout HeLa Cell Line | EDJ-KQ57550 | Human | 84217 | Details Get a Quote |
| ZMYND12 Knockout A-549 Cell Line | EDJ-KQ66047 | Human | 84217 | Details Get a Quote |
