ZKSCAN7 Gene - Zinc Finger Protein with KRAB and SCAN Domains 7
Comprehensive genomic and functional annotation of ZKSCAN7
Gene Information Card
| Symbol | ZKSCAN7 |
|---|---|
| Full Name | Zinc finger protein with KRAB and SCAN domains 7 |
| Gene Type | Protein coding |
| Chromosomal Location | 3p21.31 |
| NCBI Gene ID | 55888 ncbi.nlm.nih.gov/gene/55888 |
| Ensembl ID | ENSG00000114739 |
| UniProt ID | Q96LW9 |
| OMIM ID | 611933 |
| HGNC ID | 13107 |
| Aliases | ZNF306, ZKSCAN7, FLJ20333 |
Description
ZKSCAN7 encodes a zinc finger protein containing a KRAB (Krüppel-associated box) domain and a SCAN domain. The protein is predicted to function as a transcription factor, potentially involved in regulating gene expression through DNA binding and protein-protein interactions. The gene is located on chromosome 3p21.31, a region frequently altered in cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not established | No direct evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 8.5 | Medium |
| Brain | 5.2 | Low |
| Lung | 4.1 | Low |
| Liver | 3.8 | Low |
| Kidney | 3.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 6.0 | Moderate expression |
| K562 | 4.5 | Low expression |
| HeLa | 3.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not characterized
Gain of Function (GOF)
Not characterized
Dominant Negative (DN)
Not characterized
View complete mutation data：
Gene Ontology (GO)
| • DNA-binding transcription factor activity (GO:0003700) | • Zinc ion binding (GO:0008270) |
| • Nucleus (GO:0005634) | • DNA-templated (GO:0006355) |
Protein Summary
ZKSCAN7 is a 558-amino acid protein containing a KRAB domain (residues 1-75), a SCAN domain (residues 76-170), and multiple C2H2-type zinc finger motifs (residues 200-500). The KRAB domain mediates transcriptional repression, while the SCAN domain facilitates protein-protein interactions. The zinc fingers are predicted to bind specific DNA sequences, suggesting a role in gene regulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZKSCAN7 Knockout HEK293 Cell Line | EDJ-KQ15474 | Human | 55888 | Details Get a Quote |
| ZKSCAN7 Knockout HeLa Cell Line | EDJ-KQ47516 | Human | 55888 | Details Get a Quote |
| ZKSCAN7 Knockout A-549 Cell Line | EDJ-KQ65155 | Human | 55888 | Details Get a Quote |
| ZKSCAN7 Knockout HCT 116 Cell Line | EDJ-KQ73590 | Human | 55888 | Details Get a Quote |
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