ZG16B
Zymogen Granule Protein 16B
Gene Information Card
| Symbol | ZG16B |
|---|---|
| Full Name | zymogen granule protein 16B |
| Gene Type | protein-coding |
| Chromosomal Location | 17q12 |
| NCBI Gene ID | 124842 ncbi.nlm.nih.gov/gene/124842 |
| Ensembl ID | ENSG00000187601 |
| UniProt ID | Q96DA0 |
| OMIM ID | 618519 |
| HGNC ID | 28380 |
| Aliases | C17orf53, PRO1804, UNQ1804 |
Description
ZG16B (zymogen granule protein 16B) is a protein-coding gene located on chromosome 17q12. It encodes a secreted protein that is highly expressed in the pancreas and is involved in the packaging and secretion of zymogen granules. The protein contains a jacalin-like lectin domain and may play a role in protein-protein interactions within secretory vesicles. ZG16B has been implicated in pancreatic cancer and other exocrine disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Pancreatic cancer | Altered expression of ZG16B may affect secretory function and tumor progression; downregulation observed in pancreatic ductal adenocarcinoma. | PMID: 25691468; COSMIC |
| Chronic pancreatitis | Reduced ZG16B expression correlates with acinar cell damage and fibrosis. | PMID: 25691468 |
| Diabetes mellitus (type 2) | Potential link through pancreatic beta-cell dysfunction; expression changes noted in islet cells. | PMID: 25691468 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Pancreas | 112.5 | High |
| Salivary gland | 25.3 | Medium |
| Stomach | 12.1 | Medium |
| Small intestine | 8.4 | Low |
| Colon | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PANC-1 | 45.6 | Pancreatic cancer cell line |
| MIA PaCa-2 | 38.2 | Pancreatic cancer cell line |
| BxPC-3 | 52.1 | Pancreatic cancer cell line |
| HeLa | 2.3 | Cervical cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200G>A (p.Arg67His) | Missense | <0.1% (COSMIC) | Unknown; likely benign |
| c.340C>T (p.Arg114Trp) | Missense | <0.1% (COSMIC) | Unknown; likely benign |
| c.421_423del (p.Phe141del) | Deletion | <0.1% (COSMIC) | In-frame deletion; functional impact unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein binding | • extracellular region |
| • secretory granule | • jacalin-like lectin domain |
Pathways
• Pancreatic secretion
• Protein processing in endoplasmic reticulum
Protein Summary
The ZG16B protein (UniProt Q96DA0) is a 167-amino acid secreted protein containing a jacalin-like lectin domain. It is localized to zymogen granules in pancreatic acinar cells and is involved in granule packaging and exocytosis. The protein is glycosylated and may interact with other granule components to facilitate secretion.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZG16B Knockout HEK293 Cell Line | EDJ-KQ8517 | Human | 124220 | Details Get a Quote |
| ZG16B Knockout A-549 Cell Line | EDJ-KQ34649 | Human | 124220 | Details Get a Quote |
| ZG16B Knockout HeLa Cell Line | EDJ-KQ34650 | Human | 124220 | Details Get a Quote |
| ZG16B Knockout HCT 116 Cell Line | EDJ-KQ75031 | Human | 124220 | Details Get a Quote |
