ZG16: Zymogen Granule Protein 16
A lectin family member with roles in antimicrobial defense and potential tumor suppression
Gene Information Card
| Symbol | ZG16 |
|---|---|
| Full Name | Zymogen Granule Protein 16 |
| Gene Type | Protein coding |
| Chromosomal Location | 16p11.2 |
| NCBI Gene ID | 653808 ncbi.nlm.nih.gov/gene/653808 |
| Ensembl ID | ENSG00000161921 |
| UniProt ID | O60861 |
| OMIM ID | 615598 |
| HGNC ID | 30968 |
| Aliases | JCLN, ZG16A, ZG16B |
Description
ZG16 encodes a secreted lectin-like protein that is highly expressed in the pancreas and also found in other tissues. It binds to bacterial peptidoglycan and lipopolysaccharides, contributing to innate immune defense. ZG16 has been implicated in tumor suppression, particularly in colorectal cancer, where its expression is frequently downregulated.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Loss of ZG16 expression via promoter methylation contributes to tumor progression | PMID: 25944712 |
| Pancreatic Cancer | Reduced ZG16 expression correlates with poor prognosis | PMID: 28476881 |
| Inflammatory Bowel Disease | ZG16 may modulate gut microbiota and mucosal immunity | PMID: 31073128 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Pancreas | 1234.5 | High |
| Salivary gland | 234.6 | Medium |
| Stomach | 89.2 | Low |
| Colon | 45.1 | Low |
| Liver | 12.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PANC-1 (pancreatic) | 0.5 | Very low expression |
| Caco-2 (colorectal) | 2.1 | Low expression |
| HCT116 (colorectal) | 1.8 | Low expression |
| SW480 (colorectal) | 0.9 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Uncertain significance |
| c.100C>T | Nonsense | <0.01% | Likely loss of function |
| c.200_201del | Frameshift | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations are predicted to cause loss of function, potentially reducing antimicrobial activity and tumor suppression.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • extracellular region (GO:0005576) | • carbohydrate binding (GO:0030246) |
| • innate immune response (GO:0045087) | • extracellular space (GO:0005615) |
Pathways
• Innate immune system (Reactome: R-HSA-168249)
• Defensins (Reactome: R-HSA-1462054)
Protein Summary
ZG16 is a 16 kDa secreted protein containing a Jacalin-like lectin domain. It binds to carbohydrate moieties on bacterial surfaces, facilitating agglutination and clearance. The protein is stored in zymogen granules of pancreatic acinar cells and released into the intestinal lumen, where it contributes to mucosal immunity. Reduced expression is observed in several cancers, suggesting a tumor-suppressive role.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZG16 Knockout HEK293 Cell Line | EDJ-KQ8338 | Human | 653808 | Details Get a Quote |
| ZG16B Knockout HEK293 Cell Line | EDJ-KQ8517 | Human | 124220 | Details Get a Quote |
| ZG16B Knockout A-549 Cell Line | EDJ-KQ34649 | Human | 124220 | Details Get a Quote |
| ZG16B Knockout HeLa Cell Line | EDJ-KQ34650 | Human | 124220 | Details Get a Quote |
| ZG16 Knockout HeLa Cell Line | EDJ-KQ60664 | Human | 653808 | Details Get a Quote |
| ZG16 Knockout A-549 Cell Line | EDJ-KQ69137 | Human | 653808 | Details Get a Quote |
| ZG16B Knockout HCT 116 Cell Line | EDJ-KQ75031 | Human | 124220 | Details Get a Quote |
| ZG16 Knockout HCT 116 Cell Line | EDJ-KQ77489 | Human | 653808 | Details Get a Quote |
