ZFYVE16
Zinc Finger FYVE-Type Containing 16
Gene Information Card
| Symbol | ZFYVE16 |
|---|---|
| Full Name | Zinc Finger FYVE-Type Containing 16 |
| Gene Type | Protein coding |
| Chromosomal Location | 5q14.1 |
| NCBI Gene ID | 9765 ncbi.nlm.nih.gov/gene/9765 |
| Ensembl ID | ENSG00000113522 |
| UniProt ID | Q7Z3T8 |
| OMIM ID | 603755 |
| HGNC ID | 20756 |
| Aliases | KIAA0305, PPP1R69 |
Description
ZFYVE16 encodes a protein containing a FYVE zinc finger domain, which binds phosphatidylinositol 3-phosphate and is involved in endosomal trafficking and signaling. The protein may also function as a protein phosphatase 1 regulatory subunit.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations | Not established | No evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 10.2 | Medium |
| Lung | 8.5 | Medium |
| Liver | 6.1 | Low |
| Kidney | 7.3 | Low |
| Testis | 12.4 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.0 | High expression |
| HeLa | 9.8 | Medium expression |
| K562 | 6.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported mutations | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not characterized
Gain of Function (GOF)
Not characterized
Dominant Negative (DN)
Not characterized
View complete mutation data：
Gene Ontology (GO)
| • endosome | • phosphatidylinositol-3-phosphate binding |
| • protein phosphatase 1 binding | • endosomal transport |
Pathways
• Endosomal trafficking
• PI3K/AKT signaling (indirect)
Protein Summary
The ZFYVE16 protein contains a FYVE zinc finger domain that specifically binds phosphatidylinositol 3-phosphate, localizing it to endosomal membranes. It may regulate endosomal trafficking and act as a regulatory subunit of protein phosphatase 1.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZFYVE16 Knockout HEK293 Cell Line | EDJ-KQ411 | Human | 9765 | Details Get a Quote |
| ZFYVE16 Knockout A-549 Cell Line | EDJ-KQ18672 | Human | 9765 | Details Get a Quote |
| ZFYVE16 Knockout HCT 116 Cell Line | EDJ-KQ18673 | Human | 9765 | Details Get a Quote |
| ZFYVE16 Knockout HeLa Cell Line | EDJ-KQ18674 | Human | 9765 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
