ZFP91 Zinc Finger Protein 91
A C2H2-type zinc finger protein involved in innate immunity, NF-κB signaling, and cancer
Gene Information Card
| Symbol | ZFP91 |
|---|---|
| Full Name | ZFP91 zinc finger protein |
| Gene Type | protein-coding |
| Chromosomal Location | 11q12.1 |
| NCBI Gene ID | 80829 ncbi.nlm.nih.gov/gene/80829 |
| Ensembl ID | ENSG00000149257 |
| UniProt ID | Q96JP5 |
| OMIM ID | 611384 |
| HGNC ID | 28983 |
| Aliases | ZNF757, PZF, ZFP-91, ZNF91 |
Description
ZFP91 encodes a C2H2-type zinc finger protein that functions as a transcriptional regulator and E3 ubiquitin ligase. It is involved in the activation of NF-κB signaling, innate immune responses, and regulation of apoptosis. ZFP91 has been implicated in several cancers and inflammatory conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Overexpression of ZFP91 promotes NF-κB activation and tumor growth | PMID: 25636800 |
| Colorectal cancer | ZFP91 enhances Wnt/β-catenin signaling via ubiquitination of TCF7L2 | PMID: 31073040 |
| Hepatocellular carcinoma | ZFP91 upregulation correlates with poor prognosis and metastasis | PMID: 31570795 |
| Inflammatory bowel disease | ZFP91 modulates IL-1β and TNF-α signaling through NF-κB | PMID: 29084245 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 12.5 | Medium |
| Lymph node | 10.2 | Medium |
| Spleen | 9.8 | Medium |
| Lung | 6.3 | Low |
| Liver | 5.1 | Low |
| Testis | 4.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.3 | High expression |
| HeLa | 12.1 | Moderate expression |
| HepG2 | 8.9 | Moderate expression |
| K562 | 7.4 | Low expression |
| MCF7 | 6.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1072C>T (p.Arg358Trp) | Missense | <0.01% | Altered zinc finger domain; potential loss of DNA binding |
| c.1456G>A (p.Glu486Lys) | Missense | <0.01% | Located in ubiquitin ligase domain; may affect E3 activity |
| c.1831_1832insA (p.Thr611Asnfs*12) | Frameshift | <0.01% | Truncation; likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations in ZFP91 are predicted to cause loss of E3 ubiquitin ligase activity and impaired NF-κB signaling.
Gain of Function (GOF)
Missense mutations in the zinc finger domain may enhance DNA binding or NF-κB activation, though evidence is limited.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported for ZFP91.
View complete mutation data：
Gene Ontology (GO)
Pathways
• NF-kappa B signaling pathway (Reactome R-HSA-9013408)
• TNF signaling pathway (KEGG hsa04668)
• IL-1 signaling pathway (Reactome R-HSA-446652)
• Ubiquitin-mediated proteolysis (KEGG hsa04120)
Protein Summary
ZFP91 is a 648-amino acid protein containing multiple C2H2-type zinc finger domains and a RING-like ubiquitin ligase domain. It acts as an E3 ubiquitin ligase that targets proteins such as TCF7L2 and IκBα for ubiquitination, thereby modulating Wnt and NF-κB signaling pathways. ZFP91 is predominantly nuclear and is expressed in immune tissues and various cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZFP91 Knockout HEK293 Cell Line | EDJ-KQ9583 | Human | 80829 | Details Get a Quote |
| ZFP91 Knockout A-549 Cell Line | EDJ-KQ36409 | Human | 80829 | Details Get a Quote |
| ZFP91 Knockout HCT 116 Cell Line | EDJ-KQ36410 | Human | 80829 | Details Get a Quote |
| ZFP91 Knockout HeLa Cell Line | EDJ-KQ36411 | Human | 80829 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
