ZFAND2A Gene - Zinc Finger AN1-Type Containing 2A
Comprehensive genomic and functional annotation of ZFAND2A, a stress-responsive zinc finger protein gene.
Gene Information Card
| Symbol | ZFAND2A |
|---|---|
| Full Name | Zinc Finger AN1-Type Containing 2A |
| Gene Type | Protein coding |
| Chromosomal Location | 7p22.3 |
| NCBI Gene ID | 118426 ncbi.nlm.nih.gov/gene/118426 |
| Ensembl ID | ENSG00000106031 |
| UniProt ID | Q8N9N8 |
| OMIM ID | 618539 |
| HGNC ID | 28073 |
| Aliases | AIRAP, C7orf28, FLJ14281 |
Description
ZFAND2A (Zinc Finger AN1-Type Containing 2A) is a protein-coding gene located on chromosome 7p22.3. It encodes a stress-responsive protein that contains an AN1-type zinc finger domain. ZFAND2A is induced by arsenite and other proteotoxic stresses, and it functions in the ubiquitin-proteasome system to facilitate the degradation of misfolded proteins. The gene is also known as AIRAP (Arsenite-Inducible RNA-Associated Protein).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Proteotoxic stress-related conditions | ZFAND2A is induced under stress to enhance proteasomal degradation of misfolded proteins, potentially mitigating cellular damage. | PubMed, UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 8.2 | Medium |
| Thyroid | 6.5 | Medium |
| Adrenal gland | 5.1 | Low |
| Bone marrow | 4.8 | Low |
| Lymph node | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.1 | Moderate expression |
| HeLa | 7.3 | Moderate expression |
| K562 | 5.6 | Low expression |
| HepG2 | 4.9 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Likely loss of start codon; predicted loss of function |
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
Loss-of-function mutations in ZFAND2A are predicted to impair stress-induced proteasomal degradation, potentially increasing cellular sensitivity to proteotoxic stress.
Gain of Function (GOF)
No gain-of-function mutations have been reported.
Dominant Negative (DN)
No dominant-negative mutations have been described.
View complete mutation data：
Gene Ontology (GO)
| • zinc ion binding (GO:0008270) | • polyubiquitin modification-dependent protein binding (GO:0031593) |
| • unfolded protein binding (GO:0051082) | • ubiquitin-dependent ERAD pathway (GO:0030433) |
| • cytosol (GO:0005829) | • nucleus (GO:0005634) |
Pathways
• Proteasome-mediated ubiquitin-dependent protein catabolic process
• Cellular response to arsenite ion
• Endoplasmic reticulum-associated degradation (ERAD) pathway
Protein Summary
ZFAND2A (AIRAP) is a 207-amino acid protein containing an AN1-type zinc finger domain. It is localized to the cytosol and nucleus. Under stress conditions such as arsenite exposure, ZFAND2A is upregulated and interacts with the 19S regulatory particle of the proteasome to enhance degradation of ubiquitinated substrates. It plays a role in the cellular response to misfolded proteins and proteotoxic stress.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZFAND2A Knockout HEK293 Cell Line | EDJ-KQ10623 | Human | 90637 | Details Get a Quote |
| ZFAND2A Knockout A-549 Cell Line | EDJ-KQ38117 | Human | 90637 | Details Get a Quote |
| ZFAND2A Knockout HCT 116 Cell Line | EDJ-KQ38118 | Human | 90637 | Details Get a Quote |
| ZFAND2A Knockout HeLa Cell Line | EDJ-KQ38119 | Human | 90637 | Details Get a Quote |
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