ZDHHC24
Zinc Finger DHHC-Type Palmitoyltransferase 24
Gene Information Card
| Symbol | ZDHHC24 |
|---|---|
| Full Name | Zinc Finger DHHC-Type Palmitoyltransferase 24 |
| Gene Type | Protein coding |
| Chromosomal Location | 11q12.2 |
| NCBI Gene ID | 254359 ncbi.nlm.nih.gov/gene/254359 |
| Ensembl ID | ENSG00000149177 |
| UniProt ID | Q6P5W5 |
| OMIM ID | 617902 |
| HGNC ID | 20739 |
| Aliases | FLJ22662, ZDHHC24 |
Description
ZDHHC24 encodes a member of the DHHC palmitoyltransferase family, which catalyzes the addition of palmitate to cysteine residues of target proteins. This post-translational modification regulates protein localization, stability, and function. ZDHHC24 is involved in cellular signaling and may play a role in cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Potential oncogenic role via palmitoylation of signaling proteins | COSMIC: mutations and expression changes observed |
| Lung cancer | Altered expression may contribute to tumorigenesis | COSMIC: somatic mutations reported |
| Colorectal cancer | Possible involvement in Wnt signaling modulation | COSMIC: mutations identified |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 9.7 | Low |
| Testis | 15.2 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.1 | Embryonic kidney cells |
| HeLa | 8.5 | Cervical cancer cells |
| A549 | 7.2 | Lung cancer cells |
| MCF7 | 9.8 | Breast cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.437G>A (p.Arg146Gln) | Missense | 0.02% | Unknown functional effect |
| c.562C>T (p.Arg188Trp) | Missense | 0.01% | Unknown functional effect |
| c.748_749insA | Frameshift | 0.005% | Likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations likely lead to truncated, non-functional protein.
Gain of Function (GOF)
No evidence for gain-of-function mutations.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • Palmitoyltransferase activity | • Zinc ion binding |
| • Protein palmitoylation | • Membrane |
Pathways
• Protein palmitoylation
• Wnt signaling pathway (potential)
Protein Summary
ZDHHC24 is a 299-amino acid protein containing a conserved DHHC domain (Asp-His-His-Cys) essential for palmitoyltransferase activity. It is localized to the endoplasmic reticulum and Golgi membrane. The protein catalyzes S-palmitoylation of substrate proteins, influencing their trafficking and function.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZDHHC24 Knockout HEK293 Cell Line | EDJ-KQ11766 | Human | 254359 | Details Get a Quote |
| ZDHHC24 Knockout A-549 Cell Line | EDJ-KQ40157 | Human | 254359 | Details Get a Quote |
| ZDHHC24 Knockout HCT 116 Cell Line | EDJ-KQ40158 | Human | 254359 | Details Get a Quote |
| ZDHHC24 Knockout HeLa Cell Line | EDJ-KQ40159 | Human | 254359 | Details Get a Quote |
