ZDHHC19
Zinc Finger DHHC-Type Palmitoyltransferase 19
Gene Information Card
| Symbol | ZDHHC19 |
|---|---|
| Full Name | Zinc Finger DHHC-Type Palmitoyltransferase 19 |
| Gene Type | Protein coding |
| Chromosomal Location | 3q29 |
| NCBI Gene ID | 131540 ncbi.nlm.nih.gov/gene/131540 |
| Ensembl ID | ENSG00000163877 |
| UniProt ID | Q8WVZ1 |
| OMIM ID | 617551 |
| HGNC ID | 20719 |
| Aliases | DHHC-19, ZDHHC19A, ZDHHC19B |
Description
ZDHHC19 encodes a member of the DHHC palmitoyltransferase family, which catalyzes the addition of palmitate to cysteine residues of target proteins, influencing their localization, stability, and function. The enzyme is involved in cellular signaling and has been implicated in cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung adenocarcinoma | Overexpression of ZDHHC19 promotes cell proliferation and migration via palmitoylation of oncogenic substrates | COSMIC, literature |
| Colorectal cancer | Elevated expression correlates with poor prognosis; potential role in Wnt signaling | COSMIC, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 5.2 | Medium |
| Testis | 3.8 | Low |
| Brain | 1.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung cancer) | 8.5 | High expression |
| HCT116 (colorectal cancer) | 6.3 | Moderate expression |
| HEK293 (embryonic kidney) | 2.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.497C>T (p.Thr166Ile) | Missense | <0.1% | Unknown functional impact |
| c.832G>A (p.Gly278Arg) | Missense | <0.1% | Predicted damaging (SIFT) |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
Overexpression in cancer suggests potential gain-of-function role.
Dominant Negative (DN)
Not described.
View complete mutation data：
Gene Ontology (GO)
| • Palmitoyltransferase activity | • Protein palmitoylation |
| • Membrane | • Zinc ion binding |
Pathways
• Protein palmitoylation
• Wnt signaling (putative)
Protein Summary
ZDHHC19 is a 364-amino acid transmembrane protein with a conserved DHHC domain essential for palmitoyltransferase activity. It localizes to the endoplasmic reticulum and Golgi apparatus, modifying substrates such as Src-family kinases and G-protein coupled receptors.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZDHHC19 Knockout HEK293 Cell Line | EDJ-KQ8501 | Human | 131540 | Details Get a Quote |
| ZDHHC19 Knockout HeLa Cell Line | EDJ-KQ58299 | Human | 131540 | Details Get a Quote |
| ZDHHC19 Knockout A-549 Cell Line | EDJ-KQ66787 | Human | 131540 | Details Get a Quote |
| ZDHHC19 Knockout HCT 116 Cell Line | EDJ-KQ75190 | Human | 131540 | Details Get a Quote |
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