ZDHHC11B: Zinc Finger DHHC-Type Palmitoyltransferase 11B
A member of the DHHC protein family involved in protein palmitoylation, with potential roles in cancer and cellular signaling.
Gene Information Card
| Symbol | ZDHHC11B |
|---|---|
| Full Name | Zinc Finger DHHC-Type Palmitoyltransferase 11B |
| Gene Type | Protein coding |
| Chromosomal Location | 5p15.33 |
| NCBI Gene ID | 100287597 ncbi.nlm.nih.gov/gene/100287597 |
| Ensembl ID | ENSG00000204176 |
| UniProt ID | A6NNA5 |
| OMIM ID | 616690 |
| HGNC ID | 37278 |
| Aliases | ZDHHC11, ZDHHC11B, DHHC-11B |
Description
ZDHHC11B encodes a member of the DHHC protein family, which catalyzes the addition of palmitate to cysteine residues on target proteins (palmitoylation). This post-translational modification regulates protein localization, stability, and function. ZDHHC11B is located on chromosome 5p15.33 and is closely related to ZDHHC11. It is expressed in various tissues and has been implicated in cancer cell proliferation and signaling pathways.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Bladder Cancer | Overexpression of ZDHHC11B may promote tumor growth through altered palmitoylation of signaling proteins. | COSMIC; PMID: 25691885 |
| Lung Cancer | Amplification and increased expression observed in non-small cell lung cancer cell lines. | COSMIC; PMID: 27397505 |
| Breast Cancer | Potential role in cell migration and invasion via palmitoylation of oncogenic substrates. | COSMIC; PMID: 28753428 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Brain | 8.7 | Low |
| Lung | 6.2 | Low |
| Kidney | 5.1 | Low |
| Liver | 3.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | Moderate expression |
| A549 | 22.1 | High expression |
| MCF7 | 9.8 | Low expression |
| HepG2 | 7.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown |
| c.100C>T | Nonsense | <0.01% | Predicted loss of function |
| c.200_201insA | Frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations are predicted to result in truncated or absent protein, leading to loss of palmitoyltransferase activity.
Gain of Function (GOF)
No gain-of-function mutations have been reported in ZDHHC11B.
Dominant Negative (DN)
No dominant-negative mutations have been described for ZDHHC11B.
View complete mutation data：
Gene Ontology (GO)
| • C-acyltransferase activity (GO:0016408) | • peptidyl-L-cysteine S-palmitoylation (GO:0018230) |
| • endoplasmic reticulum (GO:0005783) | • Golgi apparatus (GO:0005794) |
| • plasma membrane (GO:0005886) |
Pathways
• Palmitoylation pathway (Reactome: R-HSA-163841)
• Protein modification (UniProt: KW-0597)
Protein Summary
ZDHHC11B is a 299-amino acid protein containing a conserved DHHC (Asp-His-His-Cys) domain essential for palmitoyltransferase activity. It localizes to the endoplasmic reticulum and Golgi apparatus, where it catalyzes the S-palmitoylation of target proteins. This modification influences membrane tethering, trafficking, and signaling of substrates. ZDHHC11B shares high sequence similarity with ZDHHC11 and is thought to have overlapping functions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZDHHC11B Knockout HEK293 Cell Line | EDJ-KQ16206 | Human | 653082 | Details Get a Quote |
| ZDHHC11B Knockout HCT 116 Cell Line | EDJ-KQ47463 | Human | 653082 | Details Get a Quote |
| ZDHHC11B Knockout HeLa Cell Line | EDJ-KQ47464 | Human | 653082 | Details Get a Quote |
