ZDHHC11
Zinc Finger DHHC-Type Palmitoyltransferase 11
Gene Information Card
| Symbol | ZDHHC11 |
|---|---|
| Full Name | Zinc Finger DHHC-Type Palmitoyltransferase 11 |
| Gene Type | Protein-coding |
| Chromosomal Location | 5p15.33 |
| NCBI Gene ID | 79844 ncbi.nlm.nih.gov/gene/79844 |
| Ensembl ID | ENSG00000164171 |
| UniProt ID | Q9H8X9 |
| OMIM ID | 617688 |
| HGNC ID | 19159 |
| Aliases | DHHC11, ZDHHC11A |
Description
ZDHHC11 encodes a member of the DHHC palmitoyltransferase family, which catalyzes the addition of palmitate to cysteine residues of target proteins. This post-translational modification regulates protein membrane localization, stability, and function. ZDHHC11 is involved in cellular signaling and has been implicated in cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Overexpression of ZDHHC11 promotes palmitoylation of oncogenic proteins, enhancing their membrane localization and signaling. | COSMIC, NCBI Gene |
| Hepatocellular carcinoma | Upregulation of ZDHHC11 correlates with poor prognosis and increased cell proliferation. | NCBI Gene, PubMed (via NCBI) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 10.2 | Low |
| Liver | 8.5 | Low |
| Testis | 15.3 | Medium |
| Lung | 6.1 | Low |
| Kidney | 7.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 12.4 | Embryonic kidney cells |
| HepG2 | 18.7 | Hepatocellular carcinoma cells |
| A549 | 9.3 | Lung carcinoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | 0.01% | Unknown functional impact |
| c.100C>T | Nonsense | 0.005% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations leading to truncated protein are predicted to impair palmitoyltransferase activity.
Gain of Function (GOF)
Not well characterized; overexpression in cancer suggests potential gain-of-function role.
Dominant Negative (DN)
No evidence currently available.
View complete mutation data：
Gene Ontology (GO)
| • protein-cysteine S-palmitoyltransferase activity (GO:0019706) | • plasma membrane (GO:0005886) |
| • integral component of membrane (GO:0016021) | • protein targeting to membrane (GO:0006612) |
Pathways
• Palmitoylation pathway
• Ras signaling (via palmitoylation of Ras family proteins)
Protein Summary
ZDHHC11 is a 364-amino acid transmembrane protein containing a conserved DHHC (Asp-His-His-Cys) cysteine-rich domain essential for palmitoyltransferase activity. It localizes to the Golgi apparatus and plasma membrane, where it palmitoylates substrates such as Ras and other signaling proteins, modulating their trafficking and function.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZDHHC11 Knockout HEK293 Cell Line | EDJ-KQ16205 | Human | 79844 | Details Get a Quote |
| ZDHHC11B Knockout HEK293 Cell Line | EDJ-KQ16206 | Human | 653082 | Details Get a Quote |
| ZDHHC11 Knockout A-549 Cell Line | EDJ-KQ47460 | Human | 79844 | Details Get a Quote |
| ZDHHC11 Knockout HCT 116 Cell Line | EDJ-KQ47461 | Human | 79844 | Details Get a Quote |
| ZDHHC11 Knockout HeLa Cell Line | EDJ-KQ47462 | Human | 79844 | Details Get a Quote |
| ZDHHC11B Knockout HCT 116 Cell Line | EDJ-KQ47463 | Human | 653082 | Details Get a Quote |
| ZDHHC11B Knockout HeLa Cell Line | EDJ-KQ47464 | Human | 653082 | Details Get a Quote |
