ZC3H15
Zinc Finger CCCH-Type Containing 15
Gene Information Card
| Symbol | ZC3H15 |
|---|---|
| Full Name | Zinc Finger CCCH-Type Containing 15 |
| Gene Type | Protein coding |
| Chromosomal Location | 2q32.1 |
| NCBI Gene ID | 55854 ncbi.nlm.nih.gov/gene/55854 |
| Ensembl ID | ENSG00000163041 |
| UniProt ID | Q5T200 |
| OMIM ID | 618435 |
| HGNC ID | 29307 |
| Aliases | DKFZp686B20107, FLJ10305, MGC131831 |
Description
ZC3H15 (zinc finger CCCH-type containing 15) is a protein-coding gene located on chromosome 2q32.1. The encoded protein contains a CCCH-type zinc finger domain, which is often involved in RNA binding and post-transcriptional regulation. ZC3H15 is ubiquitously expressed and may play roles in cellular stress responses and mRNA metabolism. Limited functional characterization is available, but its conservation across species suggests important biological functions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not established | No direct evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.8 | Medium |
| Lymph node | 10.5 | Medium |
| Spleen | 9.2 | Medium |
| Brain | 6.1 | Low |
| Liver | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.2 | Moderate expression |
| HeLa | 12.0 | Moderate expression |
| K562 | 8.5 | Low expression |
| HepG2 | 6.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T (p.Arg41Cys) | Missense | <0.01% | Unknown |
| c.456G>A (p.Val152Met) | Missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
Not established
Gain of Function (GOF)
Not established
Dominant Negative (DN)
Not established
View complete mutation data：
Gene Ontology (GO)
| • nucleic acid binding (GO:0003676) | • zinc ion binding (GO:0008270) |
| • nucleus (GO:0005634) | • cytoplasm (GO:0005737) |
Pathways
• No specific pathways curated
Protein Summary
The ZC3H15 protein (UniProt Q5T200) contains a CCCH-type zinc finger domain, characteristic of RNA-binding proteins. It is predicted to localize to the nucleus and cytoplasm. The protein is 365 amino acids long and has a molecular weight of approximately 41 kDa. Its exact molecular function remains under investigation, but it may participate in post-transcriptional gene regulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZC3H15 Knockout HEK293 Cell Line | EDJ-KQ16197 | Human | 55854 | Details Get a Quote |
| ZC3H15 Knockout A-549 Cell Line | EDJ-KQ47437 | Human | 55854 | Details Get a Quote |
| ZC3H15 Knockout HCT 116 Cell Line | EDJ-KQ47438 | Human | 55854 | Details Get a Quote |
| ZC3H15 Knockout HeLa Cell Line | EDJ-KQ47439 | Human | 55854 | Details Get a Quote |
