ZC3H12C: A Regulator of Inflammation and Immune Response
ZC3H12C (Zinc Finger CCCH-Type Containing 12C) is a protein-coding gene involved in mRNA decay and inflammatory signaling.
Gene Information Card
| Symbol | ZC3H12C |
|---|---|
| Full Name | Zinc Finger CCCH-Type Containing 12C |
| Gene Type | Protein-coding |
| Chromosomal Location | 11q22.3 |
| NCBI Gene ID | 85463 ncbi.nlm.nih.gov/gene/85463 |
| Ensembl ID | ENSG00000149257 |
| UniProt ID | Q9BQ49 |
| OMIM ID | 610493 |
| HGNC ID | 28906 |
| Aliases | MCPIP3, dJ423B22.1 |
Description
ZC3H12C encodes a member of the CCCH-type zinc finger protein family, which functions as an endoribonuclease involved in mRNA decay. The protein regulates the stability of target mRNAs, including those encoding inflammatory cytokines, thereby modulating immune and inflammatory responses. It is also implicated in cellular stress responses and differentiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Inflammatory diseases | ZC3H12C regulates mRNA stability of pro-inflammatory cytokines; dysregulation may contribute to chronic inflammation. | NCBI Gene, UniProt |
| Autoimmune disorders | Altered expression or function may affect immune homeostasis. | OMIM, NCBI Gene |
| Cancer | Potential role in tumorigenesis via regulation of oncogene or tumor suppressor mRNA stability. | COSMIC, NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 12.5 | Medium |
| Lung | 8.3 | Medium |
| Bone marrow | 7.1 | Medium |
| Lymph node | 6.9 | Medium |
| Whole blood | 5.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 | 15.0 | Leukemia cell line |
| HeLa | 10.2 | Cervical carcinoma cell line |
| HEK 293 | 8.5 | Embryonic kidney cell line |
| HepG2 | 7.8 | Hepatocellular carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1000C>T | Missense | <0.01% | Unknown |
| c.1456G>A | Missense | <0.01% | Unknown |
| c.2005_2006insA | Frameshift | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations leading to premature stop codons are predicted to cause loss of endoribonuclease activity.
Gain of Function (GOF)
No gain-of-function mutations have been reported.
Dominant Negative (DN)
No dominant-negative mutations have been characterized.
View complete mutation data：
Gene Ontology (GO)
| • endoribonuclease activity | • mRNA binding |
| • zinc ion binding | • regulation of mRNA stability |
| • inflammatory response | • immune system process |
Pathways
• mRNA surveillance pathway
• Regulation of mRNA stability by AU-rich elements
Protein Summary
ZC3H12C is a 597-amino acid protein containing a CCCH-type zinc finger domain and a PIN domain with endoribonuclease activity. It localizes to the cytoplasm and stress granules, where it degrades target mRNAs, particularly those with AU-rich elements in their 3' UTRs. This activity is crucial for controlling the expression of cytokines such as IL-6 and TNF-alpha, thereby influencing inflammation and immune responses.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZC3H12C Knockout HEK293 Cell Line | EDJ-KQ2000 | Human | 85463 | Details Get a Quote |
| ZC3H12C Knockout A-549 Cell Line | EDJ-KQ22008 | Human | 85463 | Details Get a Quote |
| ZC3H12C Knockout HCT 116 Cell Line | EDJ-KQ22009 | Human | 85463 | Details Get a Quote |
| ZC3H12C Knockout HeLa Cell Line | EDJ-KQ22010 | Human | 85463 | Details Get a Quote |
