ZC3H11B Gene
ZC3H11B: Zinc Finger CCCH-Type Containing 11B
Gene Information Card
| Symbol | ZC3H11B |
|---|---|
| Full Name | zinc finger CCCH-type containing 11B |
| Gene Type | protein-coding |
| Chromosomal Location | 1q32.1 |
| NCBI Gene ID | 100130894 ncbi.nlm.nih.gov/gene/100130894 |
| Ensembl ID | ENSG00000204103 |
| UniProt ID | A6NKD9 |
| OMIM ID | 616830 |
| HGNC ID | 33738 |
| Aliases | FLJ45831, MGC16384 |
Description
ZC3H11B is a protein-coding gene that encodes a zinc finger protein of the CCCH-type family. CCCH-type zinc finger proteins are involved in RNA binding and post-transcriptional regulation, including mRNA processing, stability, and localization. ZC3H11B is expressed in various tissues and may play a role in cellular signaling and development. The gene is located on chromosome 1q32.1.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations have been firmly established in major curated databases (OMIM, ClinVar). | Unknown | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 4.2 | Low |
| Thyroid | 3.1 | Low |
| Prostate | 2.8 | Low |
| Adrenal gland | 2.5 | Low |
| Lung | 2.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 3.5 | Low expression |
| HeLa | 2.1 | Low expression |
| K562 | 1.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No clinically significant mutations reported in COSMIC or ClinVar. | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available.
Gain of Function (GOF)
No data available.
Dominant Negative (DN)
No data available.
View complete mutation data：
Gene Ontology (GO)
| • nucleic acid binding (GO:0003676) | • zinc ion binding (GO:0008270) |
| • nucleus (GO:0005634) |
Protein Summary
The ZC3H11B protein contains a CCCH-type zinc finger domain, which is characteristic of RNA-binding proteins. It is predicted to localize to the nucleus and may be involved in RNA processing or regulation of gene expression. The precise biological function remains to be fully characterized.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZC3H11B Knockout HEK293 Cell Line | EDJ-KQ16191 | Human | 643136 | Details Get a Quote |
| ZC3H11B Knockout HCT 116 Cell Line | EDJ-KQ47429 | Human | 643136 | Details Get a Quote |
