ZBTB9
Zinc Finger and BTB Domain Containing 9
Gene Information Card
| Symbol | ZBTB9 |
|---|---|
| Full Name | Zinc finger and BTB domain containing 9 |
| Gene Type | Protein coding |
| Chromosomal Location | 6p21.32 |
| NCBI Gene ID | 221143 ncbi.nlm.nih.gov/gene/221143 |
| Ensembl ID | ENSG00000197921 |
| UniProt ID | Q96K80 |
| OMIM ID | 617830 |
| HGNC ID | 23763 |
| Aliases | MGC13125, ZNF919 |
Description
ZBTB9 encodes a zinc finger protein containing a BTB (POZ) domain, which is involved in transcriptional regulation. The protein is predicted to act as a transcription factor, potentially mediating protein-protein interactions and DNA binding. Its exact biological functions remain under investigation, but it may play roles in development and cellular differentiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 8.2 | Low |
| Spleen | 7.1 | Low |
| Bone marrow | 6.8 | Low |
| Brain | 3.4 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.2 | Moderate expression |
| K562 | 7.5 | Low expression |
| HeLa | 5.1 | Low expression |
| HepG2 | 4.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported mutations | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not characterized
Gain of Function (GOF)
Not characterized
Dominant Negative (DN)
Not characterized
View complete mutation data：
Gene Ontology (GO)
| • DNA-binding transcription factor activity | • protein homodimerization activity |
| • nucleus | • regulation of transcription by RNA polymerase II |
Protein Summary
ZBTB9 is a 506-amino acid protein containing an N-terminal BTB domain and multiple C2H2-type zinc finger motifs. The BTB domain mediates dimerization and transcriptional repression, while zinc fingers facilitate sequence-specific DNA binding. The protein is localized to the nucleus and is thought to regulate gene expression, though specific target genes are not yet identified.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZBTB9 Knockout HEK293 Cell Line | EDJ-KQ8841 | Human | 221504 | Details Get a Quote |
| ZBTB9 Knockout A-549 Cell Line | EDJ-KQ35149 | Human | 221504 | Details Get a Quote |
| ZBTB9 Knockout HCT 116 Cell Line | EDJ-KQ35150 | Human | 221504 | Details Get a Quote |
| ZBTB9 Knockout HeLa Cell Line | EDJ-KQ35151 | Human | 221504 | Details Get a Quote |
