ZBTB39
Zinc Finger and BTB Domain Containing 39
Gene Information Card
| Symbol | ZBTB39 |
|---|---|
| Full Name | Zinc Finger and BTB Domain Containing 39 |
| Gene Type | Protein coding |
| Chromosomal Location | 12q13.3 |
| NCBI Gene ID | 9887 ncbi.nlm.nih.gov/gene/9887 |
| Ensembl ID | ENSG00000135446 |
| UniProt ID | Q9NQZ2 |
| OMIM ID | 614653 |
| HGNC ID | 23763 |
| Aliases | KIAA0358, ZNF922 |
Description
ZBTB39 encodes a zinc finger protein with a BTB (POZ) domain, functioning as a transcriptional regulator. It is involved in chromatin remodeling and gene expression control, with potential roles in development and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | N/A | No direct evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.1 | Low |
| Liver | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.0 | Moderate expression |
| HeLa | 7.5 | Low expression |
| K562 | 5.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
Not established
Gain of Function (GOF)
Not established
Dominant Negative (DN)
Not established
View complete mutation data：
Gene Ontology (GO)
| • DNA-binding transcription factor activity | • zinc ion binding |
| • protein homodimerization activity | • regulation of transcription by RNA polymerase II |
Pathways
• No specific pathways curated
Protein Summary
ZBTB39 is a 584-amino acid protein containing an N-terminal BTB domain and multiple C2H2-type zinc fingers. It localizes to the nucleus and is predicted to regulate transcription through chromatin interactions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZBTB39 Knockout HEK293 Cell Line | EDC08268 | Human | 9880 | Details Get a Quote |
| ZBTB39 Knockout HeLa Cell Line | EDJ-KQ29935 | Human | 9880 | Details Get a Quote |
| ZBTB39 Knockout A-549 Cell Line | EDJ-KQ31289 | Human | 9880 | Details Get a Quote |
| ZBTB39 Knockout HCT 116 Cell Line | EDJ-KQ31290 | Human | 9880 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
