ZBTB33 (Zinc Finger and BTB Domain Containing 33)
Transcriptional repressor involved in chromatin regulation and cancer
Gene Information Card
| Symbol | ZBTB33 |
|---|---|
| Full Name | Zinc Finger and BTB Domain Containing 33 |
| Gene Type | Protein coding |
| Chromosomal Location | Xq23 |
| NCBI Gene ID | 2533 ncbi.nlm.nih.gov/gene/2533 |
| Ensembl ID | ENSG00000177485 |
| UniProt ID | Q86T24 |
| OMIM ID | 300095 |
| HGNC ID | 16760 |
| Aliases | KAISO, ZNF-kaiso, ZBTB33 |
Description
ZBTB33 (KAISO) encodes a transcriptional repressor that binds to methylated CpG dinucleotides and recruits histone deacetylase complexes to silence gene expression. It plays a role in development, cell cycle regulation, and is implicated in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | ZBTB33 overexpression promotes Wnt/β-catenin signaling by repressing negative regulators | PMID: 19029980 |
| Breast cancer | Loss of ZBTB33 expression correlates with poor prognosis and increased metastasis | PMID: 21502578 |
| Prostate cancer | ZBTB33 regulates androgen receptor signaling and tumor growth | PMID: 23431147 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Colon | 6.1 | Low |
| Breast | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.0 | High expression |
| HeLa | 10.5 | Moderate expression |
| MCF7 | 7.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.1% | Loss of function |
| c.567_568insA | Frameshift | <0.1% | Loss of function |
| c.890G>A (p.Arg297Gln) | Missense | 0.2% | Unknown |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations lead to truncated protein lacking DNA-binding or BTB domain.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • DNA-binding transcription factor activity | • chromatin binding |
| • methyl-CpG binding | • negative regulation of transcription by RNA polymerase II |
| • nucleus |
Pathways
• Wnt signaling pathway
• Transcriptional misregulation in cancer
Protein Summary
ZBTB33 (KAISO) is a 672-amino acid protein containing an N-terminal BTB/POZ domain and C-terminal zinc finger motifs. It binds methylated CpG sequences and recruits corepressor complexes to silence target genes. It is involved in cell proliferation, differentiation, and tumor suppression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZBTB33 Knockout HEK293 Cell Line | EDJ-KQ1934 | Human | 10009 | Details Get a Quote |
| ZBTB33 Knockout HCT 116 Cell Line | EDJ-KQ20571 | Human | 10009 | Details Get a Quote |
| ZBTB33 Knockout A-549 Cell Line | EDJ-KQ21866 | Human | 10009 | Details Get a Quote |
| ZBTB33 Knockout HeLa Cell Line | EDJ-KQ21867 | Human | 10009 | Details Get a Quote |
| Zbtb33 Knockout 4T1 Cell Line | EDJ-KZ86 | Mouse | 56805 | Details Get a Quote |
| Zbtb33 Knockout RM-1 [Mouse prostate carcinoma] Cell Line | EDJ-KZ87 | Mouse | 10009 | Details Get a Quote |
