ZBTB10
Zinc Finger and BTB Domain Containing 10
Gene Information Card
| Symbol | ZBTB10 |
|---|---|
| Full Name | Zinc Finger and BTB Domain Containing 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 8q21.13 |
| NCBI Gene ID | 65986 ncbi.nlm.nih.gov/gene/65986 |
| Ensembl ID | ENSG00000156113 |
| UniProt ID | Q96DT7 |
| OMIM ID | 618534 |
| HGNC ID | 29012 |
| Aliases | RINZF, ZNF436 |
Description
ZBTB10 (Zinc Finger and BTB Domain Containing 10) is a protein-coding gene that encodes a transcription factor belonging to the Krüppel-like C2H2 zinc finger family. The protein contains an N-terminal BTB (POZ) domain and multiple C2H2 zinc finger motifs, mediating protein-protein interactions and DNA binding. ZBTB10 is involved in transcriptional repression and has been implicated in cell proliferation, differentiation, and cancer biology.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | ZBTB10 may act as a tumor suppressor; downregulation associated with poor prognosis | PMID: 25670082 |
| Prostate cancer | Altered expression linked to disease progression | PMID: 23542377 |
| Colorectal cancer | Methylation-mediated silencing observed | PMID: 24675553 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.3 | Low |
| Lung | 6.1 | Low |
| Liver | 4.2 | Low |
| Kidney | 5.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 9.8 | Embryonic kidney |
| HeLa | 7.2 | Cervical carcinoma |
| MCF7 | 6.5 | Breast cancer |
| A549 | 5.1 | Lung cancer |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1123C>T | Missense | 0.01% | p.Arg375Trp; uncertain significance |
| c.1456G>A | Missense | 0.005% | p.Gly486Ser; uncertain significance |
| c.789_790del | Frameshift | 0.001% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations leading to premature stop codons are predicted to cause loss of function.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • DNA-binding transcription factor activity | • RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| • protein homodimerization activity | • negative regulation of transcription by RNA polymerase II |
| • nucleus |
Pathways
• Transcriptional regulation by ZBTB10
• p53 signaling pathway (indirect)
Protein Summary
ZBTB10 is a 674-amino acid protein with a BTB domain at the N-terminus and six C2H2 zinc fingers at the C-terminus. It localizes to the nucleus and functions as a transcriptional repressor. The BTB domain mediates homodimerization and interaction with co-repressors, while zinc fingers confer sequence-specific DNA binding. ZBTB10 is implicated in regulating genes involved in cell cycle and apoptosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZBTB10 Knockout HEK293 Cell Line | EDJ-KQ16184 | Human | 65986 | Details Get a Quote |
| ZBTB10 Knockout A-549 Cell Line | EDJ-KQ47411 | Human | 65986 | Details Get a Quote |
| ZBTB10 Knockout HCT 116 Cell Line | EDJ-KQ47412 | Human | 65986 | Details Get a Quote |
| ZBTB10 Knockout HeLa Cell Line | EDJ-KQ47413 | Human | 65986 | Details Get a Quote |
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