ZBED3
Zinc Finger BED-Type Containing 3
Gene Information Card
| Symbol | ZBED3 |
|---|---|
| Full Name | Zinc Finger BED-Type Containing 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 5q13.3 |
| NCBI Gene ID | 84327 ncbi.nlm.nih.gov/gene/84327 |
| Ensembl ID | ENSG00000164171 |
| UniProt ID | Q96IU2 |
| OMIM ID | 614247 |
| HGNC ID | 28987 |
| Aliases | C5orf5, FLJ12529 |
Description
ZBED3 (Zinc Finger BED-Type Containing 3) is a protein-coding gene located on chromosome 5q13.3. It encodes a protein with a BED-type zinc finger domain, which is characteristic of DNA-binding proteins involved in transcriptional regulation. The gene is conserved in vertebrates and is expressed in various tissues. Its precise biological functions are not fully characterized, but it may play roles in development and cellular signaling.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 8.2 | Medium |
| Brain | 4.5 | Low |
| Lung | 3.1 | Low |
| Liver | 2.0 | Low |
| Kidney | 1.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 6.0 | Moderate expression |
| HeLa | 4.2 | Low expression |
| K562 | 3.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • DNA binding | • zinc ion binding |
| • nucleus | • transcription regulation |
Protein Summary
The ZBED3 protein contains a BED-type zinc finger domain, which is a DNA-binding motif. It is predicted to localize to the nucleus and may function as a transcription factor. The protein is 363 amino acids long with a molecular weight of approximately 40 kDa. Its exact cellular roles remain under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZBED3 Knockout HEK293 Cell Line | EDJ-KQ10069 | Human | 84327 | Details Get a Quote |
| ZBED3 Knockout A-549 Cell Line | EDJ-KQ37123 | Human | 84327 | Details Get a Quote |
| ZBED3 Knockout HCT 116 Cell Line | EDJ-KQ37124 | Human | 84327 | Details Get a Quote |
| ZBED3 Knockout HeLa Cell Line | EDJ-KQ37125 | Human | 84327 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
