ZBED11 (Zinc Finger BED-Type Containing 11)
A poorly characterized zinc finger protein with potential roles in gene regulation and cancer.
Gene Information Card
| Symbol | ZBED11 |
|---|---|
| Full Name | Zinc finger BED-type containing 11 |
| Gene Type | protein coding |
| Chromosomal Location | 1p36.33 |
| NCBI Gene ID | 100130776 ncbi.nlm.nih.gov/gene/100130776 |
| Ensembl ID | ENSG00000235151 |
| UniProt ID | A6NHL2 |
| OMIM ID | Not available |
| HGNC ID | HGNC:37263 |
| Aliases | FLJ45850 |
Description
ZBED11 is a protein-coding gene located on chromosome 1p36.33. It encodes a zinc finger protein of the BED-type family, which is characterized by a BED finger domain involved in protein-DNA and protein-protein interactions. The gene is poorly characterized, but its expression has been detected in various tissues and cell lines. ZBED11 has been implicated in certain cancers, though its exact biological functions remain under investigation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Potential involvement in tumorigenesis; altered expression observed in cancer cell lines. | COSMIC: expression and mutation data; limited clinical evidence. |
| Lung cancer | Possible role in cell proliferation; expression changes noted in cancer tissues. | COSMIC: mutation data; no direct functional studies. |
| Colorectal cancer | Mutations and expression alterations reported in cancer samples. | COSMIC: mutation data; no direct functional studies. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | Not available | Low expression |
| Thyroid | Not available | Low expression |
| Adrenal gland | Not available | Low expression |
| Bone marrow | Not available | Low expression |
| Lymph node | Not available | Low expression |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | Not available | Expression detected in RNA-seq |
| A549 (lung cancer) | Not available | Expression detected in RNA-seq |
| HCT116 (colorectal cancer) | Not available | Expression detected in RNA-seq |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234A>G (p.Thr412Ala) | Missense | Rare (COSMIC) | Unknown; predicted benign in silico |
| c.567C>T (p.Pro189Leu) | Missense | Rare (COSMIC) | Unknown; predicted possibly damaging in silico |
| c.890_891insA (frameshift) | Insertion | Rare (COSMIC) | Likely loss of function; not characterized |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations may lead to truncated protein and loss of function, but no functional studies confirm this.
Gain of Function (GOF)
No evidence for gain-of-function mutations.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • DNA binding (GO:0003677) | • Zinc ion binding (GO:0008270) |
| • DNA-templated (GO:0006355) |
Pathways
• No specific pathways curated in Reactome or KEGG for ZBED11.
Protein Summary
ZBED11 encodes a protein of 456 amino acids (UniProt A6NHL2) containing a BED-type zinc finger domain. The BED finger is a conserved motif found in proteins involved in chromatin organization and transcriptional regulation. The protein is predicted to localize to the nucleus and may bind DNA. However, its precise molecular function and interacting partners remain unknown. Expression data suggest low levels in normal tissues, with some upregulation in cancer cell lines, hinting at a possible role in oncogenesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZBED11 Knockout HEK293 Cell Line | EDJ-KQ13418 | Human | 285550 | Details Get a Quote |
| ZBED11 Knockout A-549 Cell Line | EDJ-KQ42945 | Human | 285550 | Details Get a Quote |
| ZBED11 Knockout HCT 116 Cell Line | EDJ-KQ42946 | Human | 285550 | Details Get a Quote |
| ZBED11 Knockout HeLa Cell Line | EDJ-KQ42947 | Human | 285550 | Details Get a Quote |
