ZBED1
Zinc Finger BED-Type Containing 1
Gene Information Card
| Symbol | ZBED1 |
|---|---|
| Full Name | Zinc Finger BED-Type Containing 1 |
| Gene Type | protein-coding |
| Chromosomal Location | Xp22.33 |
| NCBI Gene ID | 9189 ncbi.nlm.nih.gov/gene/9189 |
| Ensembl ID | ENSG00000114771 |
| UniProt ID | O96006 |
| OMIM ID | 300897 |
| HGNC ID | 11696 |
| Aliases | DREF, TRAMP, hDREF, ZBED |
Description
ZBED1 (Zinc Finger BED-Type Containing 1) encodes a transcription factor that binds to the DRE (DNA replication-related element) sequence and activates genes involved in cell proliferation, including those encoding histones and DNA replication factors. It plays a role in chromatin regulation and cell cycle progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No direct evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 8.2 | Low |
| Bone marrow | 7.1 | Low |
| Spleen | 6.8 | Low |
| Other tissues | <5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K562 | 10.3 | Leukemia cell line |
| HeLa | 8.9 | Cervical cancer cell line |
| HEK293 | 7.5 | Embryonic kidney cell line |
| HepG2 | 6.2 | Liver cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown functional effect |
| c.100C>T | missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • DNA-binding transcription factor activity | • chromatin binding |
| • regulation of transcription | • DNA-templated |
| • cell cycle | • nucleus |
Pathways
• DNA replication
• Cell cycle
Protein Summary
ZBED1 is a 594-amino acid protein containing a BED-type zinc finger domain that mediates sequence-specific DNA binding. It localizes to the nucleus and activates transcription of target genes involved in DNA replication and cell cycle control.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZBED11 Knockout HEK293 Cell Line | EDJ-KQ13418 | Human | 285550 | Details Get a Quote |
| ZBED11 Knockout A-549 Cell Line | EDJ-KQ42945 | Human | 285550 | Details Get a Quote |
| ZBED11 Knockout HCT 116 Cell Line | EDJ-KQ42946 | Human | 285550 | Details Get a Quote |
| ZBED11 Knockout HeLa Cell Line | EDJ-KQ42947 | Human | 285550 | Details Get a Quote |
| ZBED1 Knockout HEK293 Cell Line | EDJ-KQ50850 | Human | 9189 | Details Get a Quote |
| ZBED1 Knockout HeLa Cell Line | EDJ-KQ55100 | Human | 9189 | Details Get a Quote |
| ZBED1 Knockout A-549 Cell Line | EDJ-KQ63580 | Human | 9189 | Details Get a Quote |
| ZBED1 Knockout HCT 116 Cell Line | EDJ-KQ72047 | Human | 9189 | Details Get a Quote |
