YPEL2 Gene - Yippee Like 2
Comprehensive genomic and proteomic analysis of YPEL2, a member of the Yippee-like family involved in cellular processes.
Gene Information Card
| Symbol | YPEL2 |
|---|---|
| Full Name | Yippee Like 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 17q22 |
| NCBI Gene ID | 388403 ncbi.nlm.nih.gov/gene/388403 |
| Ensembl ID | ENSG00000187601 |
| UniProt ID | Q5JTD0 |
| OMIM ID | 611679 |
| HGNC ID | 26295 |
| Aliases | YIP2, FLJ14640 |
Description
YPEL2 (Yippee Like 2) is a protein-coding gene located on chromosome 17q22. It belongs to the Yippee-like family, which is evolutionarily conserved and implicated in cell cycle regulation, apoptosis, and development. The encoded protein contains a zinc-finger-like domain and may function in cellular stress responses and protein-protein interactions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not established | No direct evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 8.5 | Medium |
| Brain | 4.2 | Low |
| Lung | 3.1 | Low |
| Liver | 2.0 | Low |
| Kidney | 1.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 5.0 | Moderate expression |
| HeLa | 3.5 | Low expression |
| K562 | 2.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.307C>T (p.Arg103Trp) | Missense | <0.01% | Unknown functional impact |
| c.458G>A (p.Arg153Gln) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • nucleus (GO:0005634) |
| • cytoplasm (GO:0005737) | • zinc ion binding (GO:0008270) |
Protein Summary
The YPEL2 protein (UniProt Q5JTD0) is a 139-amino-acid polypeptide with a predicted molecular weight of 15.6 kDa. It contains a conserved Yippee domain and a zinc-finger-like motif, suggesting involvement in metal ion binding and protein interactions. The protein is localized to the nucleus and cytoplasm, and may play roles in cell proliferation and stress response.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| YPEL2 Knockout HEK293 Cell Line | EDJ-KQ16171 | Human | 388403 | Details Get a Quote |
| YPEL2 Knockout A-549 Cell Line | EDJ-KQ46147 | Human | 388403 | Details Get a Quote |
| YPEL2 Knockout HCT 116 Cell Line | EDJ-KQ47382 | Human | 388403 | Details Get a Quote |
| YPEL2 Knockout HeLa Cell Line | EDJ-KQ47383 | Human | 388403 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
