YES1 Gene (YES Proto-Oncogene, Src Family Tyrosine Kinase)
Comprehensive genomic and functional analysis of YES1, a Src-family kinase implicated in cancer and cell signaling.
Gene Information Card
| Symbol | YES1 |
|---|---|
| Full Name | YES proto-oncogene 1, Src family tyrosine kinase |
| Gene Type | protein-coding |
| Chromosomal Location | 18p11.32 |
| NCBI Gene ID | 7525 ncbi.nlm.nih.gov/gene/7525 |
| Ensembl ID | ENSG00000176105 |
| UniProt ID | P07947 |
| OMIM ID | 164880 |
| HGNC ID | 12841 |
| Aliases | c-yes, Yes, p61-Yes |
Description
YES1 (YES proto-oncogene 1) encodes a member of the Src family of non-receptor tyrosine kinases. The protein is involved in cell growth, survival, migration, and differentiation through phosphorylation of downstream signaling molecules. Overexpression and activating mutations are associated with various cancers, including colorectal, lung, and breast cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | YES1 overexpression and amplification drive proliferation via Src signaling | PMID: 25485619; COSMIC |
| Non-small cell lung cancer | YES1 amplification confers resistance to EGFR inhibitors | PMID: 29301962; ClinVar |
| Breast cancer | YES1 overexpression correlates with poor prognosis and metastasis | PMID: 21804532; NCBI Gene |
| Gastric cancer | YES1 activation promotes tumor growth and invasion | PMID: 26014227; COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.3 | Medium |
| Colon | 8.7 | Medium |
| Breast | 6.5 | Low |
| Liver | 4.2 | Low |
| Brain | 1.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung) | 15.2 | High expression |
| HCT116 (colon) | 10.1 | Medium expression |
| MCF7 (breast) | 7.8 | Medium expression |
| HEK293 (embryonic kidney) | 5.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.158C>T (p.Thr53Ile) | Missense | <0.1% | Unknown; likely benign |
| c.1045G>A (p.Glu349Lys) | Missense | <0.1% | Unknown; reported in COSMIC |
| Amplification | Copy number gain | 1-5% in cancers | Gain-of-function; associated with resistance to tyrosine kinase inhibitors |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in YES1.
Gain of Function (GOF)
Amplification and overexpression lead to increased kinase activity and oncogenic signaling.
Dominant Negative (DN)
Not described for YES1.
View complete mutation data：
Gene Ontology (GO)
Pathways
• hsa04020 - Calcium signaling pathway
• hsa04510 - Focal adhesion
• hsa04660 - T cell receptor signaling pathway
• hsa05200 - Pathways in cancer
Protein Summary
YES1 is a 543-amino acid protein (UniProt P07947) with an N-terminal SH4 domain for membrane localization, SH3 and SH2 domains for protein-protein interactions, and a C-terminal tyrosine kinase domain. It is activated by autophosphorylation at Tyr426 and negatively regulated by phosphorylation at Tyr537 by CSK. YES1 transduces signals from growth factor receptors, integrins, and immune receptors, regulating cell adhesion, migration, and proliferation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| YES1 Knockout HEK293 Cell Line | EDJ-KQ17848 | Human | 7525 | Details Get a Quote |
| YES1 Knockout A-549 Cell Line | EDJ-KQ23027 | Human | 7525 | Details Get a Quote |
| YES1 Knockout HCT 116 Cell Line | EDJ-KQ23028 | Human | 7525 | Details Get a Quote |
| YES1 Knockout HeLa Cell Line | EDJ-KQ23029 | Human | 7525 | Details Get a Quote |
