YEATS4 Gene
YEATS Domain Containing 4 – Transcriptional Regulator and Oncogene
Gene Information Card
| Symbol | YEATS4 |
|---|---|
| Full Name | YEATS domain containing 4 |
| Gene Type | Protein coding |
| Chromosomal Location | 12q15 |
| NCBI Gene ID | 8089 ncbi.nlm.nih.gov/gene/8089 |
| Ensembl ID | ENSG00000135446 |
| UniProt ID | O95619 |
| OMIM ID | 613741 |
| HGNC ID | 24845 |
| Aliases | GAS41, NuBI-1, YAF9, FLJ10916 |
Description
YEATS4 (YEATS domain containing 4), also known as GAS41, is a protein-coding gene located on chromosome 12q15. It encodes a component of the NuA4 histone acetyltransferase complex and the SWR1-like chromatin remodeling complex. YEATS4 functions as a transcriptional regulator by recognizing crotonyllysine and acetyllysine on histones, thereby influencing chromatin structure and gene expression. It is implicated in cell proliferation, apoptosis, and oncogenesis, with overexpression observed in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Glioma | YEATS4 overexpression promotes tumor growth and invasion via chromatin remodeling | PMID: 25670082 |
| Breast cancer | Amplification and overexpression of YEATS4 drive cell cycle progression | PMID: 27397505 |
| Lung cancer | YEATS4 acts as an oncogene by enhancing MYC transcriptional activity | PMID: 29056339 |
| Colorectal cancer | YEATS4 upregulation correlates with poor prognosis and metastasis | PMID: 30464215 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 28.5 | High |
| Brain | 15.2 | Medium |
| Lung | 12.8 | Medium |
| Breast | 10.1 | Medium |
| Colon | 8.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 22.3 | Cervical cancer cell line |
| A549 | 18.7 | Lung cancer cell line |
| MCF7 | 15.4 | Breast cancer cell line |
| U87MG | 20.1 | Glioblastoma cell line |
| HCT116 | 14.9 | Colorectal cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.374C>T (p.Thr125Met) | Missense | 0.02% | Unknown functional impact |
| c.487G>A (p.Gly163Arg) | Missense | 0.01% | Reported in COSMIC |
| c.1A>G (p.Met1Val) | Start loss | 0.005% | Likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Start loss mutations (e.g., p.Met1Val) are predicted to abolish protein expression.
Gain of Function (GOF)
Amplification and overexpression of YEATS4 in cancers suggest oncogenic gain-of-function.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for YEATS4.
View complete mutation data：
Gene Ontology (GO)
Pathways
• NuA4 histone acetyltransferase complex
• SWR1-like chromatin remodeling complex
• MYC transcriptional activation pathway
• Notch signaling pathway
Protein Summary
YEATS4 (GAS41) is a 227-amino acid protein containing a YEATS domain that specifically recognizes crotonyllysine and acetyllysine on histone tails. It is a core component of the NuA4/TIP60 histone acetyltransferase complex and the SWR1-like chromatin remodeling complex. Through these complexes, YEATS4 regulates chromatin dynamics, transcription, DNA repair, and cell cycle progression. Overexpression of YEATS4 is oncogenic in multiple cancer types, and its expression is associated with poor prognosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| No Data | ||||
