YBX1 Gene: Y-Box Binding Protein 1 - Function, Disease Associations, and Expression
Comprehensive resource on YBX1 (Y-box binding protein 1), including gene card, expression, mutations, and clinical significance.
Gene Information Card
| Symbol | YBX1 |
|---|---|
| Full Name | Y-box binding protein 1 |
| Gene Type | protein coding |
| Chromosomal Location | 1p34.2 |
| NCBI Gene ID | 4904 ncbi.nlm.nih.gov/gene/4904 |
| Ensembl ID | ENSG00000065978 |
| UniProt ID | P67809 |
| OMIM ID | 154030 |
| HGNC ID | 12813 |
| Aliases | YB-1, BP-8, CSDA2, EFI-A, MGC104858, MGC110976, MGC118710, MGC118711, MGC118712, MGC118713, MGC118714, NSEP1, YBX-1 |
Description
YBX1 encodes the Y-box binding protein 1, a multifunctional protein involved in transcription, translation, RNA splicing, DNA repair, and stress response. It binds to Y-box elements in promoters and to RNA, regulating gene expression at multiple levels. YBX1 is implicated in cell proliferation, differentiation, and apoptosis, and is overexpressed in many cancers, contributing to tumor progression, drug resistance, and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (multiple types) | Overexpression of YBX1 promotes cell proliferation, invasion, and chemoresistance via regulation of genes like EGFR, MYC, and ABCB1. | High expression correlates with poor prognosis in breast, lung, colorectal, and ovarian cancers (multiple studies). |
| Prostate cancer | YBX1 is overexpressed and associated with aggressive disease; it regulates androgen receptor signaling. | Immunohistochemistry and mRNA studies show elevated YBX1 in prostate tumors. |
| Renal cell carcinoma | YBX1 expression is elevated and linked to tumor progression and metastasis. | Studies show YBX1 promotes epithelial-mesenchymal transition (EMT) in renal cancer cells. |
| Inflammatory diseases | YBX1 modulates inflammatory responses via regulation of cytokine expression. | Preclinical models suggest YBX1 involvement in inflammation, but clinical evidence is limited. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Breast | 12.3 | Medium |
| Lung | 8.7 | Low |
| Colon | 10.5 | Medium |
| Kidney | 9.2 | Low |
| Liver | 6.4 | Low |
| Brain | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa (cervical cancer) | 15.2 | High expression |
| MCF7 (breast cancer) | 18.4 | High expression |
| A549 (lung cancer) | 11.3 | Medium expression |
| HepG2 (liver cancer) | 7.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.317A>G (p.Asp106Gly) | Missense | Rare (0.01% in gnomAD) | Unknown functional effect; not clinically significant. |
| c.500C>T (p.Pro167Leu) | Missense | Rare (0.005%) | No known disease association. |
| c.1000G>A (p.Ala334Thr) | Missense | Rare (0.002%) | No known disease association. |
Mutation functional classification
Loss of Function (LOF)
No clear loss-of-function mutations reported; YBX1 is essential for cell viability, and complete loss is likely lethal.
Gain of Function (GOF)
Overexpression or amplification of YBX1 is common in cancers, acting as an oncogene by enhancing cell proliferation and survival.
Dominant Negative (DN)
No dominant-negative mutations described; however, some mutations may alter protein interactions, but evidence is lacking.
View complete mutation data：
Gene Ontology (GO)
| • DNA binding | • RNA binding |
| • transcription factor activity | • mRNA binding |
| • translation regulator activity | • protein binding |
| • nucleic acid binding | • single-stranded DNA binding |
| • double-stranded DNA binding | • mRNA 5'-UTR binding |
Pathways
• mRNA surveillance
• Translation regulation
• Cellular response to stress
• DNA damage response
• p53 signaling pathway
• Apoptosis
• Cell cycle
• Cancer pathways
Protein Summary
YBX1 is a 36 kDa protein with a cold-shock domain (CSD) that binds to Y-box sequences in DNA and RNA. It shuttles between nucleus and cytoplasm, regulating transcription, translation, and mRNA stability. Post-translational modifications (phosphorylation, ubiquitination) modulate its activity. YBX1 is overexpressed in many cancers and is a potential therapeutic target.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| YBX1 Knockout HEK293 Cell Line | EDJ-KQ50489 | Human | 4904 | Details Get a Quote |
| YBX1 Knockout HeLa Cell Line | EDJ-KQ54026 | Human | 4904 | Details Get a Quote |
| YBX1 Knockout A-549 Cell Line | EDJ-KQ62515 | Human | 4904 | Details Get a Quote |
| YBX1 Knockout HCT 116 Cell Line | EDJ-KQ70987 | Human | 4904 | Details Get a Quote |
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