WNT8B
Wnt Family Member 8B: A Key Regulator in Developmental Signaling and Oncogenesis
Gene Information Card
| Symbol | WNT8B |
|---|---|
| Full Name | Wnt Family Member 8B |
| Gene Type | protein-coding |
| Chromosomal Location | 10q24.31 |
| NCBI Gene ID | 7479 ncbi.nlm.nih.gov/gene/7479 |
| Ensembl ID | ENSG00000175264 |
| UniProt ID | Q93098 |
| OMIM ID | 601396 |
| HGNC ID | 12789 |
| Aliases | WNT8D, WNT-8B |
Description
WNT8B is a member of the WNT gene family, which encodes secreted signaling proteins involved in embryogenesis, cell polarity, and tissue homeostasis. WNT8B specifically plays a role in the canonical Wnt/β-catenin pathway, regulating cell proliferation and differentiation during development. Aberrant expression or mutation of WNT8B has been implicated in various cancers and developmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | WNT8B overexpression activates β-catenin signaling, promoting tumor growth | COSMIC, NCBI |
| Breast Cancer | Upregulation of WNT8B correlates with poor prognosis and metastasis | COSMIC, NCBI |
| Gastric Cancer | WNT8B amplification drives Wnt pathway activation | COSMIC, NCBI |
| Hepatocellular Carcinoma | WNT8B overexpression contributes to cell proliferation | COSMIC, NCBI |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 0.3 | Low |
| Heart | 0.1 | Low |
| Kidney | 0.2 | Low |
| Liver | 0.1 | Low |
| Lung | 0.2 | Low |
| Placenta | 0.5 | Medium |
| Testis | 0.4 | Medium |
| Uterus | 0.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.2 | Low expression |
| HeLa | 0.1 | Low expression |
| MCF7 | 0.3 | Low expression |
| A549 | 0.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown functional impact |
| c.100C>T | missense | <0.1% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
Overexpression in cancers suggests potential gain-of-function via increased Wnt signaling.
Dominant Negative (DN)
No dominant-negative mutations documented.
View complete mutation data：
Gene Ontology (GO)
| • extracellular region | • Wnt signaling pathway |
| • cell surface receptor signaling pathway | • cell proliferation |
| • embryonic development |
Pathways
• Wnt signaling pathway (KEGG: hsa04310)
• Hippo signaling pathway (KEGG: hsa04390)
• Signaling by WNT (Reactome: R-HSA-195721)
Protein Summary
WNT8B encodes a 351-amino-acid secreted glycoprotein that binds to Frizzled receptors to activate the canonical Wnt/β-catenin pathway. The protein contains a signal peptide for secretion and conserved cysteine residues typical of Wnt family members. It is involved in embryonic patterning and cell fate determination.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| WNT8B Knockout HEK293 Cell Line | EDJ-KQ357 | Human | 7479 | Details Get a Quote |
| WNT8B Knockout HeLa Cell Line | EDJ-KQ54754 | Human | 7479 | Details Get a Quote |
| WNT8B Knockout A-549 Cell Line | EDJ-KQ63249 | Human | 7479 | Details Get a Quote |
| WNT8B Knockout HCT 116 Cell Line | EDJ-KQ71713 | Human | 7479 | Details Get a Quote |
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