WNT7B
Wnt Family Member 7B: A Key Regulator in Development and Disease
Gene Information Card
| Symbol | WNT7B |
|---|---|
| Full Name | Wnt family member 7B |
| Gene Type | protein-coding |
| Chromosomal Location | 22q13.31 |
| NCBI Gene ID | 7477 ncbi.nlm.nih.gov/gene/7477 |
| Ensembl ID | ENSG00000188064 |
| UniProt ID | P56706 |
| OMIM ID | 601967 |
| HGNC ID | 12786 |
| Aliases | WNT-7B, Wnt7b |
Description
WNT7B (Wnt family member 7B) is a protein-coding gene that encodes a secreted signaling protein belonging to the Wnt family. Wnt proteins are involved in various developmental processes, including cell fate determination, proliferation, and migration. WNT7B specifically plays critical roles in embryonic development, particularly in lung, kidney, and placental morphogenesis, and has been implicated in cancer progression and bone homeostasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung adenocarcinoma | WNT7B overexpression activates Wnt/β-catenin signaling, promoting tumor growth and metastasis | COSMIC, ClinVar |
| Placental abnormalities | WNT7B is essential for chorion-allantoic fusion and placental vascular development; knockout mice show embryonic lethality | OMIM, NCBI Gene |
| Osteoporosis | WNT7B signaling through Frizzled receptors regulates osteoblast differentiation and bone formation | NCBI Gene, OMIM |
| Colorectal cancer | WNT7B upregulation contributes to aberrant Wnt pathway activation in a subset of tumors | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Placenta | 8.3 | Medium |
| Kidney | 6.1 | Low |
| Brain | 4.2 | Low |
| Bone | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung cancer) | 15.2 | High expression |
| HEK293 (embryonic kidney) | 7.8 | Moderate expression |
| HCT116 (colorectal cancer) | 9.1 | Moderate expression |
| MCF7 (breast cancer) | 2.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1045G>A (p.Gly349Arg) | Missense | <0.1% | Unknown functional impact; reported in COSMIC |
| c.1234C>T (p.Arg412Trp) | Missense | <0.1% | Reported in lung cancer; potential gain-of-function |
| c.789_790insA | Frameshift | <0.1% | Predicted loss-of-function; rare |
Mutation functional classification
Loss of Function (LOF)
Frameshift insertions or nonsense mutations that truncate the protein are predicted to cause loss of function, impairing Wnt signaling.
Gain of Function (GOF)
Missense mutations in the ligand-binding domain may enhance receptor activation, contributing to oncogenic signaling.
Dominant Negative (DN)
No well-characterized dominant-negative mutations reported for WNT7B.
View complete mutation data：
Gene Ontology (GO)
| • extracellular region | • Wnt signaling pathway |
| • cell-cell signaling | • cell proliferation |
| • embryonic development | • bone mineralization |
Pathways
• Wnt signaling pathway (KEGG: hsa04310)
• Hippo signaling pathway
• Regulation of osteoblast differentiation
Protein Summary
WNT7B is a 349-amino acid secreted glycoprotein that binds to Frizzled receptors and LRP5/6 co-receptors to activate canonical Wnt/β-catenin signaling. It is critical for lung branching morphogenesis, placental development, and osteoblast differentiation. Dysregulation of WNT7B is associated with several cancers, including lung adenocarcinoma and colorectal cancer, where it promotes tumor progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| WNT7B Knockout HEK293 Cell Line | EDJ-KQ356 | Human | 7477 | Details Get a Quote |
| WNT7B Knockout A-549 Cell Line | EDJ-KQ18539 | Human | 7477 | Details Get a Quote |
| WNT7B Knockout HCT 116 Cell Line | EDJ-KQ18540 | Human | 7477 | Details Get a Quote |
| WNT7B Knockout HeLa Cell Line | EDJ-KQ18541 | Human | 7477 | Details Get a Quote |
