WIPF3
WAS/WASL Interacting Protein Family Member 3
Gene Information Card
| Symbol | WIPF3 |
|---|---|
| Full Name | WAS/WASL Interacting Protein Family Member 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q31.1 |
| NCBI Gene ID | 644150 ncbi.nlm.nih.gov/gene/644150 |
| Ensembl ID | ENSG00000162923 |
| UniProt ID | Q9H4E5 |
| OMIM ID | 609964 |
| HGNC ID | 24919 |
| Aliases | CR16, WIP-related protein, WIRE |
Description
WIPF3 (WAS/WASL Interacting Protein Family Member 3) encodes a protein that belongs to the WASP-interacting protein (WIP) family. The encoded protein interacts with WASP and N-WASP, regulating actin cytoskeleton dynamics. It is involved in cell motility, vesicle trafficking, and signal transduction. WIPF3 is expressed in various tissues, with highest levels in the brain and testis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 10.2 | Medium |
| Testis | 8.5 | Medium |
| Lung | 4.1 | Low |
| Kidney | 3.8 | Low |
| Liver | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 6.3 | Moderate expression |
| HeLa | 4.7 | Low expression |
| K562 | 2.1 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic mutations reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • actin binding | • protein binding |
| • actin cytoskeleton organization | • cell migration |
| • signal transduction |
Pathways
• Regulation of actin cytoskeleton
• WASP/WAVE signaling
Protein Summary
WIPF3 is a 503-amino acid protein that contains a WASP homology domain and a proline-rich region. It binds to WASP and N-WASP, promoting actin polymerization. The protein is implicated in cytoskeletal remodeling and cellular protrusion formation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| WIPF3 Knockout HEK293 Cell Line | EDJ-KQ16143 | Human | 644150 | Details Get a Quote |
| WIPF3 Knockout HCT 116 Cell Line | EDJ-KQ47323 | Human | 644150 | Details Get a Quote |
| WIPF3 Knockout HeLa Cell Line | EDJ-KQ60566 | Human | 644150 | Details Get a Quote |
| WIPF3 Knockout A-549 Cell Line | EDJ-KQ69036 | Human | 644150 | Details Get a Quote |
