WFIKKN2 Gene
WAP, Follistatin/Kazal, Immunoglobulin, Kunitz and Netrin Domain Containing 2
Gene Information Card
| Symbol | WFIKKN2 |
|---|---|
| Full Name | WAP, Follistatin/Kazal, Immunoglobulin, Kunitz and Netrin Domain Containing 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q21.33 |
| NCBI Gene ID | 124857 ncbi.nlm.nih.gov/gene/124857 |
| Ensembl ID | ENSG00000173714 |
| UniProt ID | Q8TEU8 |
| OMIM ID | 610895 |
| HGNC ID | 30938 |
| Aliases | WFIKKN, hWFIKKN, FLJ20174 |
Description
WFIKKN2 encodes a multidomain protein containing WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domains. It is a secreted protein that may function as a protease inhibitor and play a role in extracellular matrix regulation and cell signaling.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association confirmed | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.1 | Low |
| Liver | 4.3 | Low |
| Kidney | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.0 | Moderate expression |
| HeLa | 8.5 | Low expression |
| K562 | 5.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not characterized
Gain of Function (GOF)
Not characterized
Dominant Negative (DN)
Not characterized
View complete mutation data：
Gene Ontology (GO)
| • serine-type endopeptidase inhibitor activity | • extracellular region |
| • protein binding |
Pathways
• No known pathway associations
Protein Summary
The WFIKKN2 protein is a secreted multidomain protein with potential protease inhibitory functions. It contains a WAP domain, a follistatin/kazal domain, an immunoglobulin domain, a kunitz domain, and a netrin domain. Its exact biological role remains under investigation, but it may be involved in extracellular matrix remodeling and cell adhesion.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| WFIKKN2 Knockout HEK293 Cell Line | EDJ-KQ8638 | Human | 124857 | Details Get a Quote |
| WFIKKN2 Knockout HeLa Cell Line | EDJ-KQ58142 | Human | 124857 | Details Get a Quote |
| WFIKKN2 Knockout A-549 Cell Line | EDJ-KQ66628 | Human | 124857 | Details Get a Quote |
| WFIKKN2 Knockout HCT 116 Cell Line | EDJ-KQ75045 | Human | 124857 | Details Get a Quote |
