WFIKKN1
WAP, Follistatin/Kazal, Immunoglobulin, Kunitz and Netrin Domain Containing 1
Gene Information Card
| Symbol | WFIKKN1 |
|---|---|
| Full Name | WAP, Follistatin/Kazal, Immunoglobulin, Kunitz and Netrin Domain Containing 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 17p13.3 |
| NCBI Gene ID | 117166 ncbi.nlm.nih.gov/gene/117166 |
| Ensembl ID | ENSG00000141574 |
| UniProt ID | Q96NZ8 |
| OMIM ID | 609207 |
| HGNC ID | 30934 |
| Aliases | WFIKKN, WFIKKN1, WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 |
Description
The WFIKKN1 gene encodes a multidomain protein containing WAP, follistatin/Kazal, immunoglobulin, Kunitz, and netrin domains. It is thought to function as a protease inhibitor and may play a role in extracellular matrix regulation and cell signaling. The gene is located on chromosome 17p13.3 and is expressed in various tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease associations currently curated in ClinVar or OMIM | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Prostate | 8.2 | Low |
| Adrenal gland | 6.1 | Low |
| Thyroid | 5.4 | Low |
| Lung | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.2 | Moderate expression |
| HeLa | 7.5 | Low expression |
| K562 | 3.1 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • serine-type endopeptidase inhibitor activity | • extracellular region |
| • protein binding |
Pathways
• No curated pathways
Protein Summary
The WFIKKN1 protein is a secreted multidomain inhibitor that contains a WAP domain, a follistatin/Kazal domain, an immunoglobulin domain, a Kunitz domain, and a netrin domain. It is predicted to inhibit serine proteases and may modulate growth factor signaling. The protein is expressed in several tissues, with highest levels in testis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| WFIKKN1 Knockout HEK293 Cell Line | EDJ-KQ7598 | Human | 117166 | Details Get a Quote |
| WFIKKN1 Knockout HeLa Cell Line | EDJ-KQ58007 | Human | 117166 | Details Get a Quote |
| WFIKKN1 Knockout A-549 Cell Line | EDJ-KQ66495 | Human | 117166 | Details Get a Quote |
| WFIKKN1 Knockout HCT 116 Cell Line | EDJ-KQ74914 | Human | 117166 | Details Get a Quote |
