WFDC11: WAP Four-Disulfide Core Domain 11
A member of the WFDC family of protease inhibitors with potential roles in innate immunity and cancer
Gene Information Card
| Symbol | WFDC11 |
|---|---|
| Full Name | WAP four-disulfide core domain 11 |
| Gene Type | protein-coding |
| Chromosomal Location | 20q13.12 |
| NCBI Gene ID | 259239 ncbi.nlm.nih.gov/gene/259239 |
| Ensembl ID | ENSG00000125870 |
| UniProt ID | Q8NFP4 |
| OMIM ID | 617575 |
| HGNC ID | 28335 |
| Aliases | WAP11, dJ222E13.5 |
Description
WFDC11 encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The protein contains a conserved WAP domain characteristic of serine protease inhibitors. WFDC11 is expressed in various tissues, particularly in the respiratory and reproductive tracts, and is implicated in innate immune responses and epithelial barrier function. Its expression is dysregulated in certain cancers, suggesting a potential role in tumorigenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Overexpression of WFDC11 may promote tumor growth through protease inhibition altering extracellular matrix remodeling. | COSMIC; PMID: 25691885 |
| Lung cancer | Altered WFDC11 expression correlates with poor prognosis; potential role in immune evasion. | NCBI Gene; PMID: 28431212 |
| Inflammatory airway disease | WFDC11 modulates protease activity in airway epithelium, contributing to inflammation. | UniProt; PMID: 21525035 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Prostate | 8.3 | Low |
| Trachea | 15.1 | Medium |
| Testis | 6.7 | Low |
| Salivary gland | 9.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung carcinoma) | 14.2 | High expression |
| PC-3 (prostate cancer) | 7.5 | Moderate expression |
| HeLa (cervical cancer) | 3.1 | Low expression |
| MCF7 (breast cancer) | 2.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200G>A (p.Arg67His) | Missense | 0.01% (gnomAD) | Unknown functional impact |
| c.347C>T (p.Thr116Met) | Missense | 0.005% (gnomAD) | Predicted benign |
| c.123_124insA | Frameshift | <0.001% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.123_124insA) predicted to cause premature truncation and loss of WAP domain.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
Not documented.
View complete mutation data：
Gene Ontology (GO)
Pathways
• REACT:14797 – Innate Immune System
• REACT:16888 – Signaling by WNT (indirect via protease regulation)
Protein Summary
WFDC11 is a secreted protein of approximately 12 kDa containing a single WAP domain. It functions as a serine protease inhibitor, likely regulating proteolytic cascades in epithelial tissues. The protein is involved in antimicrobial defense and tissue homeostasis. Structural studies indicate a conserved four-disulfide core typical of the WFDC family.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| WFDC11 Knockout HEK293 Cell Line | EDJ-KQ16141 | Human | 259239 | Details Get a Quote |
| WFDC11 Knockout HeLa Cell Line | EDJ-KQ47322 | Human | 259239 | Details Get a Quote |
| WFDC11 Knockout A-549 Cell Line | EDJ-KQ67795 | Human | 259239 | Details Get a Quote |
| WFDC11 Knockout HCT 116 Cell Line | EDJ-KQ76181 | Human | 259239 | Details Get a Quote |
