WEE2 Gene - WEE2 Oocyte Meiosis Inhibiting Kinase
Essential regulator of oocyte meiotic maturation and cell cycle control
Gene Information Card
| Symbol | WEE2 |
|---|---|
| Full Name | WEE2 oocyte meiosis inhibiting kinase |
| Gene Type | protein-coding |
| Chromosomal Location | 7q34 |
| NCBI Gene ID | 494551 ncbi.nlm.nih.gov/gene/494551 |
| Ensembl ID | ENSG00000164830 |
| UniProt ID | P0C1S8 |
| OMIM ID | 614084 |
| HGNC ID | 33104 |
| Aliases | WEE1B, WEE1 homolog 2 |
Description
WEE2 (WEE2 oocyte meiosis inhibiting kinase) is a protein-coding gene that encodes a nuclear tyrosine kinase belonging to the WEE family. This kinase plays a critical role in maintaining meiotic arrest in oocytes by phosphorylating and inactivating cyclin-dependent kinase 1 (CDK1), thereby preventing premature meiotic resumption. WEE2 is essential for female fertility, and mutations in this gene are associated with human oocyte maturation defects and zygotic cleavage failure.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Female infertility due to oocyte maturation defect | Loss-of-function mutations in WEE2 impair CDK1 phosphorylation, leading to failure of meiotic arrest and abnormal oocyte maturation | ClinVar, OMIM |
| Zygotic cleavage failure | Biallelic WEE2 mutations prevent proper cell cycle progression after fertilization, causing early embryonic arrest | PubMed, ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Ovary | 12.5 | Medium |
| Testis | 0.8 | Low |
| Fallopian tube | 0.5 | Low |
| Endometrium | 0.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 | 0.2 | Low expression |
| HeLa | 0.1 | Very low expression |
| HEK 293 | 0.1 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | Rare | Loss of start codon, likely loss of function |
| c.157C>T (p.Arg53*) | Nonsense | Rare | Premature stop, loss of function |
| c.368G>A (p.Arg123Gln) | Missense | Rare | Impaired kinase activity, loss of function |
Mutation functional classification
Loss of Function (LOF)
Most reported WEE2 mutations are loss-of-function, leading to reduced or absent kinase activity and failure to inhibit CDK1, causing meiotic arrest defects.
Gain of Function (GOF)
No gain-of-function mutations have been reported for WEE2.
Dominant Negative (DN)
No dominant-negative mutations have been described for WEE2.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Cell cycle - G2/M checkpoint (Reactome: R-HSA-69481)
• Oocyte meiosis (KEGG: hsa04114)
Protein Summary
WEE2 is a 646-amino acid nuclear kinase that specifically inhibits CDK1 via phosphorylation at tyrosine 15. It is highly expressed in oocytes and is essential for maintaining prophase I arrest. The protein contains an N-terminal regulatory domain and a C-terminal catalytic kinase domain. WEE2 is distinct from WEE1 in its preferential expression in germ cells and its non-redundant role in female meiosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| WEE2 Knockout HEK293 Cell Line | EDJ-KQ11202 | Human | 494551 | Details Get a Quote |
| WEE2 Knockout HeLa Cell Line | EDJ-KQ60485 | Human | 494551 | Details Get a Quote |
| WEE2 Knockout A-549 Cell Line | EDJ-KQ68955 | Human | 494551 | Details Get a Quote |
| WEE2 Knockout HCT 116 Cell Line | EDJ-KQ77314 | Human | 494551 | Details Get a Quote |
