WBP2NL
WBP2 N-terminal like gene
Gene Information Card
| Symbol | WBP2NL |
|---|---|
| Full Name | WBP2 N-terminal like |
| Gene Type | protein-coding |
| Chromosomal Location | 22q13.33 |
| NCBI Gene ID | 283383 ncbi.nlm.nih.gov/gene/283383 |
| Ensembl ID | ENSG00000183087 |
| UniProt ID | Q6ICG8 |
| OMIM ID | 610981 |
| HGNC ID | 28496 |
| Aliases | WBP2NL, WBP2 N-terminal like, FLJ32709 |
Description
WBP2NL (WBP2 N-terminal like) is a protein-coding gene located on chromosome 22q13.33. It is predominantly expressed in testis and is thought to play a role in spermatogenesis. The encoded protein contains a WW domain-binding motif and may interact with WW domain-containing proteins. Limited functional data are available.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Other tissues | <1.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Testis cell lines | Not available | No data in GTEx or HPA |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not established
Gain of Function (GOF)
Not established
Dominant Negative (DN)
Not established
View complete mutation data：
Protein Summary
The WBP2NL protein is predicted to be a small, testis-specific protein with a WW domain-binding motif. Its exact molecular function and cellular role remain largely uncharacterized.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| WBP2NL Knockout HEK293 Cell Line | EDJ-KQ16128 | Human | 164684 | Details Get a Quote |
| WBP2NL Knockout HeLa Cell Line | EDJ-KQ58880 | Human | 164684 | Details Get a Quote |
| WBP2NL Knockout A-549 Cell Line | EDJ-KQ67371 | Human | 164684 | Details Get a Quote |
| WBP2NL Knockout HCT 116 Cell Line | EDJ-KQ75763 | Human | 164684 | Details Get a Quote |
