VPS37B
VPS37B subunit of ESCRT-I complex
Gene Information Card
| Symbol | VPS37B |
|---|---|
| Full Name | VPS37B subunit of ESCRT-I |
| Gene Type | protein-coding |
| Chromosomal Location | 12q24.31 |
| NCBI Gene ID | 79720 ncbi.nlm.nih.gov/gene/79720 |
| Ensembl ID | ENSG00000139618 |
| UniProt ID | Q9H9H4 |
| OMIM ID | 610903 |
| HGNC ID | 26097 |
| Aliases | HCRP1, MGC33214 |
Description
VPS37B (VPS37B subunit of ESCRT-I) encodes a component of the endosomal sorting complex required for transport I (ESCRT-I). This complex is essential for multivesicular body (MVB) formation, sorting of ubiquitinated membrane proteins into intraluminal vesicles, and downregulation of activated receptors. VPS37B is involved in cytokinesis, HIV-1 budding, and autophagy. Mutations or dysregulation of VPS37B have been implicated in cancer progression and neurodegenerative disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | Reduced VPS37B expression correlates with poor prognosis; may impair receptor downregulation | PMID: 23149919 |
| Breast cancer | Low VPS37B expression associated with aggressive tumor features and shorter survival | PMID: 23792583 |
| Prostate cancer | VPS37B downregulation linked to increased invasion and metastasis | PMID: 25605248 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 10.2 | Medium |
| Breast | 8.5 | Medium |
| Prostate | 7.1 | Medium |
| Brain | 4.3 | Low |
| Lung | 6.8 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 12.5 | Hepatocellular carcinoma cell line |
| MCF7 | 9.8 | Breast cancer cell line |
| PC3 | 6.2 | Prostate cancer cell line |
| HEK293 | 11.0 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Loss of start codon; likely loss of function |
| c.325C>T (p.Arg109Trp) | Missense | <0.01% | Unknown functional effect |
| c.487_489del (p.Lys163del) | In-frame deletion | <0.01% | May disrupt ESCRT-I assembly |
Mutation functional classification
Loss of Function (LOF)
Loss-of-function mutations in VPS37B impair ESCRT-I function, leading to defective receptor downregulation and enhanced growth signaling.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • endosomal transport | • protein ubiquitination |
| • multivesicular body assembly | • viral budding |
| • cytokinesis | • autophagy |
Pathways
• ESCRT-I complex
• Endosomal sorting
• HIV-1 budding
• EGFR downregulation
Protein Summary
VPS37B is a 285-amino acid protein that forms part of the ESCRT-I complex, which also includes VPS28, VPS37A/C/D, and TSG101. It contains a mod(r) domain and a coiled-coil region. VPS37B localizes to endosomal membranes and is required for the sorting of ubiquitinated cargo into intraluminal vesicles. It also participates in abscission during cytokinesis and in the release of enveloped viruses such as HIV-1.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| VPS37B Knockout HEK293 Cell Line | EDJ-KQ16109 | Human | 79720 | Details Get a Quote |
| VPS37B Knockout A-549 Cell Line | EDJ-KQ47275 | Human | 79720 | Details Get a Quote |
| VPS37B Knockout HCT 116 Cell Line | EDJ-KQ47276 | Human | 79720 | Details Get a Quote |
| VPS37B Knockout HeLa Cell Line | EDJ-KQ47277 | Human | 79720 | Details Get a Quote |
