VPREB1
Pre-B Lymphocyte Gene 1
Gene Information Card
| Symbol | VPREB1 |
|---|---|
| Full Name | Pre-B Lymphocyte Gene 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 22q11.22 |
| NCBI Gene ID | 7441 ncbi.nlm.nih.gov/gene/7441 |
| Ensembl ID | ENSG00000169575 |
| UniProt ID | P12018 |
| OMIM ID | 605141 |
| HGNC ID | 12712 |
| Aliases | IGVPB, VpreB, CD179a |
Description
VPREB1 encodes a component of the surrogate light chain, which is expressed on the surface of pre-B cells and plays a critical role in B cell development. It associates with the immunoglobulin heavy chain to form the pre-B cell receptor, facilitating the transition from pro-B to pre-B cell stage.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| B-cell acute lymphoblastic leukemia (B-ALL) | VPREB1 rearrangements (e.g., with PAX5) drive leukemogenesis | PMID: 17344846 |
| Multiple myeloma | VPREB1 expression is aberrantly upregulated in some myeloma cells | PMID: 11134221 |
| Immunodeficiency | Mutations affecting pre-BCR signaling impair B cell development | PMID: 10631119 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone Marrow | 0.0 | Not detected |
| Lymph Node | 0.0 | Not detected |
| Spleen | 0.0 | Not detected |
| Thymus | 0.0 | Not detected |
| Whole Blood | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| NALM6 (B-ALL) | 0.0 | Not expressed in this cell line |
| REH (B-ALL) | 0.0 | Not expressed |
| K562 (CML) | 0.0 | Not expressed |
| HEK293 (embryonic kidney) | 0.0 | Not expressed |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| PAX5-VPREB1 fusion | Translocation | Rare in B-ALL | Oncogenic fusion protein disrupts B cell differentiation |
| VPREB1 deletion | Loss | Rare | Impaired pre-BCR formation |
Mutation functional classification
Loss of Function (LOF)
Deletions or inactivating mutations impair pre-BCR assembly, blocking B cell development at the pro-B stage.
Gain of Function (GOF)
Not described.
Dominant Negative (DN)
Not described.
View complete mutation data：
Gene Ontology (GO)
| • immunoglobulin receptor binding | • antigen binding |
| • B cell receptor signaling pathway | • pre-B cell receptor assembly |
| • cell surface |
Pathways
• Pre-B cell receptor signaling
• B cell receptor signaling
• Immunoglobulin light chain biosynthesis
Protein Summary
The VPREB1 protein (VpreB1) is a 145-amino acid polypeptide that forms the surrogate light chain together with λ5 (IGLL1). It is expressed on the surface of early B cells and is essential for pre-B cell receptor function, which drives clonal expansion and immunoglobulin gene rearrangement.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| VPREB1 Knockout HEK293 Cell Line | EDJ-KQ6008 | Human | 7441 | Details Get a Quote |
| VPREB1 Knockout HeLa Cell Line | EDJ-KQ54741 | Human | 7441 | Details Get a Quote |
| VPREB1 Knockout A-549 Cell Line | EDJ-KQ63235 | Human | 7441 | Details Get a Quote |
| VPREB1 Knockout HCT 116 Cell Line | EDJ-KQ71699 | Human | 7441 | Details Get a Quote |
