VN1R5 Gene - Vomeronasal 1 Receptor 5
Comprehensive genomic and functional analysis of VN1R5, a putative pheromone receptor.
Gene Information Card
| Symbol | VN1R5 |
|---|---|
| Full Name | Vomeronasal 1 Receptor 5 |
| Gene Type | protein-coding |
| Chromosomal Location | 5q32 |
| NCBI Gene ID | 317705 ncbi.nlm.nih.gov/gene/317705 |
| Ensembl ID | ENSG00000186188 |
| UniProt ID | Q8NG97 |
| OMIM ID | 611242 |
| HGNC ID | 19699 |
| Aliases | V1RL5, V1r-like 5, VN1R5P |
Description
VN1R5 (Vomeronasal 1 Receptor 5) is a protein-coding gene located on chromosome 5q32. It encodes a member of the vomeronasal type 1 receptor family, which are G protein-coupled receptors (GPCRs) implicated in pheromone detection. The gene is considered a pseudogene in humans due to a frameshift mutation, but its transcript is still detected in some tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease associations currently curated | Not applicable | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.2 | Low |
| Adrenal gland | 0.1 | Low |
| Brain (cortex) | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | Not detected |
| K562 | 0.0 | Not detected |
| HepG2 | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs61750900 | frameshift | 0.5% (gnomAD) | Loss of function (pseudogene) |
| rs143713195 | missense | 0.1% | Unknown |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutation rs61750900 introduces a premature stop codon, rendering the protein non-functional.
Gain of Function (GOF)
No gain-of-function variants reported.
Dominant Negative (DN)
No dominant-negative variants reported.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity (GO:0004930) | • pheromone receptor activity (GO:0016503) |
| • plasma membrane (GO:0005886) |
Pathways
• Olfactory transduction (KEGG:04740)
Protein Summary
The VN1R5 protein is a 314-amino acid GPCR with seven transmembrane domains. In humans, it is considered a pseudogene due to a frameshift mutation, and no functional protein is produced. Orthologs in other mammals are involved in pheromone sensing.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| VN1R5 Knockout HEK293 Cell Line | EDJ-KQ8888 | Human | 317705 | Details Get a Quote |
| VN1R5 Knockout A-549 Cell Line | EDJ-KQ35213 | Human | 317705 | Details Get a Quote |
| VN1R5 Knockout HCT 116 Cell Line | EDJ-KQ35214 | Human | 317705 | Details Get a Quote |
| VN1R5 Knockout HeLa Cell Line | EDJ-KQ35215 | Human | 317705 | Details Get a Quote |
