VN1R4 Gene - Vomeronasal 1 Receptor 4
Genetic and functional insights into the vomeronasal receptor VN1R4
Gene Information Card
| Symbol | VN1R4 |
|---|---|
| Full Name | Vomeronasal 1 receptor 4 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.42 |
| NCBI Gene ID | 317705 ncbi.nlm.nih.gov/gene/317705 |
| Ensembl ID | ENSG00000205558 |
| UniProt ID | Q8NGZ9 |
| OMIM ID | 611626 |
| HGNC ID | 23268 |
| Aliases | V1RL4, V1r-like 4 |
Description
VN1R4 encodes a vomeronasal type-1 receptor, a member of the G protein-coupled receptor family. These receptors are typically involved in pheromone detection in the vomeronasal organ, though in humans the organ is vestigial. The gene is located in a cluster of vomeronasal receptor genes on chromosome 19. Its exact physiological role in humans remains under investigation, but it may be involved in chemosensory signaling.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No direct evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.0 | Not detected |
| Adipose tissue | 0.0 | Not detected |
| Brain | 0.0 | Not detected |
| Liver | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No cell line data | N/A | No expression reported in common cell lines |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • pheromone binding |
| • integral component of membrane | • signal transduction |
Pathways
• G alpha (i) signaling events
• Olfactory signaling pathway
Protein Summary
VN1R4 is a 7-transmembrane G protein-coupled receptor. It is predicted to localize to the plasma membrane and may function in pheromone detection. The protein is 330 amino acids long and contains conserved cysteine residues typical of GPCRs. Its expression in humans is extremely low, suggesting a possible non-functional or pseudogene-like status in some populations.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| VN1R4 Knockout HEK293 Cell Line | EDJ-KQ8889 | Human | 317703 | Details Get a Quote |
| VN1R4 Knockout HeLa Cell Line | EDJ-KQ59569 | Human | 317703 | Details Get a Quote |
| VN1R4 Knockout A-549 Cell Line | EDJ-KQ68034 | Human | 317703 | Details Get a Quote |
| VN1R4 Knockout HCT 116 Cell Line | EDJ-KQ76414 | Human | 317703 | Details Get a Quote |
